Engineering Research Center for Nanomaterials, Henan University, Kaifeng, 475004, China.
Henan Engineering Research Center of Industrial Circulating Water Treatment, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China.
Mikrochim Acta. 2022 Sep 8;189(10):376. doi: 10.1007/s00604-022-05468-2.
A novel near-infrared (NIR) light-triggered smart nanoplatform has been developed for cancer targeting and imaging-guided combined photothermal-chemo treatment. Notably, AgS has a dual function of photothermal therapy and fluorescence imaging, which greatly simplifies the structure of the system. It can emit fluorescence at 820 nm under an excitation wavelength of 560 nm. The phase-change molecule of 1-tetradecanol (TD) is introduced as a temperature-sensitive gatekeeper to provide the nanocarrier with controlled release capability of doxorubicin (DOX). The nanocarrier (HAgS@mSiO-TD/DOX) shows a high drug loading capacity of 26.3% and exhibits an apparent NIR-responsive DOX release property. Under NIR irradiation, the photothermal effect of HAgS nanocores facilitated the release of DOX through the melting of TD. The cytotoxicity test shows that the nanocarriers have good biocompatibility. As the same time, the synergistic combination leads to a better cancer inhibition effect than individual therapy alone in vitro. Cell uptake tests indicate that the carriers have excellent fluorescence imaging ability and high cellular uptake for HepG2 cells. This work provides a new strategy for the fabrication of smart nanocarriers with simple structures for fluorescence-mediated combination cancer therapy. Fabrication of a smart drug delivery system based on hollow AgS@mSiO nanoparticles for fluorescence-guided synergistic photothermal chemotherapy.
一种新型的近红外（NIR）光触发智能纳米平台已经被开发出来，用于癌症靶向和成像引导的光热化疗联合治疗。值得注意的是，AgS 具有光热治疗和荧光成像的双重功能，这大大简化了系统的结构。它可以在 560nm 的激发波长下发射 820nm 的荧光。相变分子十四醇（TD）被引入作为温度敏感的守门员，为纳米载体提供阿霉素（DOX）的控制释放能力。纳米载体（HAgS@mSiO-TD/DOX）具有 26.3%的高载药能力，并表现出明显的近红外响应 DOX 释放特性。在近红外照射下，HAgS 纳米核的光热效应通过 TD 的熔化促进了 DOX 的释放。细胞毒性试验表明，纳米载体具有良好的生物相容性。同时，协同组合导致体外的癌症抑制效果优于单独治疗。细胞摄取试验表明，载体具有优异的荧光成像能力和对 HepG2 细胞的高细胞摄取能力。这项工作为制备具有简单结构的荧光介导联合癌症治疗的智能纳米载体提供了一种新策略。基于中空 AgS@mSiO 纳米粒子的智能药物传递系统的构建，用于荧光引导的协同光热化疗。
