Tanahashi Nobuyuki, Takagi Ken, Amagasu Nozomi, Wang Guifeng, Mizuno Kaito, Kawanoguchi Jun, Yi Guo, Ishida Torao
Institute of Traditional Chinese Medicine, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan.
Institute of Traditional Chinese Medicine, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan; Tianjin University of TCM, Tianjin 300193, China.
Neurosci Lett. 2016 Apr 8;618:99-103. doi: 10.1016/j.neulet.2016.02.051. Epub 2016 Mar 3.
Depression is a kind of mood disorder. The incidence of depressed patients has demonstrated an upward trend in recent years. Symptoms may improve with treatments such as pharmacotherapy and cognitive-behavioral therapy, but such approaches may exert strong side effects, and therapeutic effects can be slow. We studied how acupuncture stimulation would affect depression as a method to reduce side effects. Mild depression was induced in rats by 1-week water-immersion stress. We treated these mildly depressed rats with either acupuncture stimulation at the "Bai-Hui" (GV 20) and "Yintáng" (Ex-HN3) points, or antidepressants. We then measured the immobile time and serum corticosterone level in rats. Immobile time and serum corticosterone level decreased on stimulation with acupuncture or antidepressants. These findings suggest that mild depression in rats was improved by stimulation with acupuncture The mechanisms underlying such improvement may effect HPA system activated by this stress, and inhibit the response to lead to the disorder of the hippocampal nerve cell.
抑郁症是一种情绪障碍。近年来，抑郁症患者的发病率呈上升趋势。通过药物治疗和认知行为疗法等治疗方法，症状可能会有所改善，但这些方法可能会产生强烈的副作用，而且治疗效果可能较慢。我们研究了针刺刺激作为一种减少副作用的方法如何影响抑郁症。通过1周的水浸应激在大鼠中诱导轻度抑郁。我们用针刺刺激“百会”（GV 20）和“印堂”（Ex-HN3）穴位或抗抑郁药治疗这些轻度抑郁的大鼠。然后我们测量了大鼠的不动时间和血清皮质酮水平。针刺或抗抑郁药刺激后，不动时间和血清皮质酮水平降低。这些发现表明，针刺刺激可改善大鼠的轻度抑郁。这种改善的潜在机制可能影响由这种应激激活的HPA系统，并抑制导致海马神经细胞紊乱的反应。
