伴有浆细胞分化的B细胞非霍奇金淋巴瘤

B-cell Non-Hodgkin Lymphomas with Plasmacytic Differentiation.

作者信息

Harmon Charles M, Smith Lauren B

机构信息

Department of Pathology, University of Michigan Hospitals and Health Systems, 1301 Catherine Street, Ann Arbor, MI 48109, USA.

Department of Pathology, University of Michigan Hospitals and Health Systems, 5320 Medical Science I, 1301 Catherine Street, Ann Arbor, MI 48109-5602, USA.

出版信息

Surg Pathol Clin. 2016 Mar;9(1):11-28. doi: 10.1016/j.path.2015.09.007.

DOI:10.1016/j.path.2015.09.007

PMID:26940265

Abstract

B-cell non-Hodgkin lymphomas with plasmacytic differentiation are a diverse group of entities with extremely variable morphologic features. Diagnostic challenges can arise in differentiating lymphoplasmacytic lymphoma from marginal zone lymphoma and other low-grade B-cell lymphomas. In addition, plasmablastic lymphomas can be difficult to distinguish from diffuse large B-cell lymphoma or other high-grade lymphomas. Judicious use of immunohistochemical studies and molecular testing can assist in appropriate classification.

摘要

具有浆细胞分化的B细胞非霍奇金淋巴瘤是一组形态学特征极为多样的实体瘤。在鉴别淋巴浆细胞淋巴瘤与边缘区淋巴瘤及其他低级别B细胞淋巴瘤时可能会面临诊断挑战。此外，浆母细胞淋巴瘤可能难以与弥漫性大B细胞淋巴瘤或其他高级别淋巴瘤相区分。合理运用免疫组化研究和分子检测有助于进行恰当的分类。