Department of Hematopathology, The Universityof Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Am J Clin Pathol. 2011 Aug;136(2):195-210. doi: 10.1309/AJCP8FOIVTB6LBER.
Small B-cell lymphomas with plasmacytic differentiation frequently present diagnostic challenges. Session 3 of the 2009 Society for Hematopathology/European Association for Haematopathology Workshop focused on lymphoplasmacytic lymphoma (LPL). The submitted cases illustrated classic examples of bone marrow-based and nodal LPL and cases with atypical features, including unusual phenotypes or involvement of extranodal sites. Several cases showed varying degrees of overlap with marginal zone lymphoma, and, as acknowledged in the 2008 World Health Organization classification, a definitive distinction between these 2 possibilities cannot always be established. Session 6 of the workshop focused on other non-marginal zone lymphomas that may display plasmacytic differentiation. This session highlights the wide variety of neoplasms that enter into the differential diagnosis of small B-cell lymphomas with plasmacytic differentiation and demonstrates the use of clinical features and ancillary studies in establishing an appropriate diagnosis by 2008 World Health Organization criteria.
具有浆细胞分化的小 B 细胞淋巴瘤常带来诊断挑战。2009 年血液病理学协会/欧洲血液病理学协会研讨会的第 3 场重点关注淋巴浆细胞淋巴瘤（LPL）。提交的病例展示了基于骨髓和淋巴结的 LPL 的典型例子，以及具有非典型特征的病例，包括不常见的表型或涉及结外部位。一些病例显示出与边缘区淋巴瘤不同程度的重叠，并且，正如 2008 年世界卫生组织分类所承认的，这两种可能性之间的明确区分并非总是能够确立。研讨会的第 6 场重点关注其他可能显示浆细胞分化的非边缘区淋巴瘤。本场重点突出了许多不同的肿瘤，它们都可能进入浆细胞分化的小 B 细胞淋巴瘤的鉴别诊断，并展示了如何根据 2008 年世界卫生组织标准，使用临床特征和辅助研究来建立适当的诊断。
