AP-HP, Hotel Dieu, Service d’Anatomie et de CytologiePathologiques, Universite Paris Descartes, Paris, France.
Am J Clin Pathol. 2011 Aug;136(2):211-25. doi: 10.1309/AJCP63OGXHXCSKSC.
Marginal zone lymphomas of all types (nodal, splenic, and extranodal mucosa-associated lymphoid tissue [MALT]) may show plasmacytic differentiation. Distinguishing marginal zone lymphomas from other small B-cell lymphomas with plasmacytic differentiation, especially lymphoplasmacytic lymphoma, or from plasma cell neoplasms may be challenging. Marginal zone lymphomas with plasmacytic differentiation were discussed in 2 sessions of the 2009 Society for Hematopathology/European Association for Haematopathology Workshop. Session 4 focused on nodal marginal zone lymphomas, including cases exhibiting classic features and cases displaying atypical phenotypes. The difficulties of classification of cases with increased numbers of large cells were also discussed. Session 5 examined nonnodal marginal zone lymphomas and related entities, including splenic marginal zone lymphoma, MALT lymphoma, γ heavy chain disease, and cryoglobulin-associated lymphoproliferative disorders. These cases illustrate the importance of clinical data and, in some cases, phenotypic and cytogenetic findings in appropriately applying the 2008 World Health Organization criteria.
所有类型的边缘区淋巴瘤（结内、脾和结外黏膜相关淋巴组织[MALT]）都可能表现出浆细胞分化。鉴别边缘区淋巴瘤与其他具有浆细胞分化的小 B 细胞淋巴瘤，尤其是淋巴浆细胞淋巴瘤，或与浆细胞瘤可能具有挑战性。2009 年血液病理学协会/欧洲血液病理学协会研讨会进行了 2 次关于具有浆细胞分化的边缘区淋巴瘤的讨论。第 4 次会议侧重于结内边缘区淋巴瘤，包括表现出典型特征和表现出非典型表型的病例。还讨论了细胞数量增加的病例分类的困难。第 5 次会议检查了非结内边缘区淋巴瘤和相关实体，包括脾边缘区淋巴瘤、MALT 淋巴瘤、γ重链病和冷球蛋白血症相关的淋巴增生性疾病。这些病例说明了临床数据的重要性，在某些情况下，表型和细胞遗传学发现对于正确应用 2008 年世界卫生组织标准也很重要。
