Timmerman Ilse, Daniel Anna E, Kroon Jeffrey, van Buul Jaap D
Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.
Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.
Int Rev Cell Mol Biol. 2016;322:281-329. doi: 10.1016/bs.ircmb.2015.10.005. Epub 2016 Jan 13.
Leukocytes cross the endothelial vessel wall in a process called transendothelial migration (TEM). The purpose of leukocyte TEM is to clear the causing agents of inflammation in underlying tissues, for example, bacteria and viruses. During TEM, endothelial cells initiate signals that attract and guide leukocytes to sites of tissue damage. Leukocytes react by attaching to these sites and signal their readiness to move back to endothelial cells. Endothelial cells in turn respond by facilitating the passage of leukocytes while retaining overall integrity. In this review, we present recent findings in the field and we have endeavored to synthesize a coherent picture of the intricate interplay between endothelial cells and leukocytes during TEM.
白细胞通过一个称为跨内皮迁移（TEM）的过程穿过内皮血管壁。白细胞TEM的目的是清除潜在组织中的炎症致病因子，例如细菌和病毒。在TEM过程中，内皮细胞启动信号，吸引并引导白细胞至组织损伤部位。白细胞通过附着于这些部位做出反应，并表明它们准备好回到内皮细胞。内皮细胞则通过促进白细胞通过同时保持整体完整性做出回应。在本综述中，我们展示了该领域的最新发现，并努力梳理出一幅关于TEM过程中内皮细胞与白细胞之间复杂相互作用的连贯图景。
