Chetan Ioana-Maria, Vesa Ștefan Cristian, Domokos Gergely Bianca, Beyer Ruxandra Stefana, Tomoaia Raluca, Cabau Georgiana, Vulturar Damiana Maria, Pop Dana, Todea Doina
Department of Pneumology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Biomedicines. 2023 Dec 24;12(1):48. doi: 10.3390/biomedicines12010048.
(1) Background: Although obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity, the link between OSA and cardiovascular disease (CVD) is not completely elucidated. Thus, we aim to assess cardiovascular risk (CVR) using SCORE 2 and SCORE 2 for older persons (SCORE 2OP), and to evaluate the association between the endothelial biomarkers VCAM-1, ICAM-1, epicardial fat, and sleep study parameters in order to improve current clinical practices and better understand the short-and long-term CVRs in OSA patients. (2) Methods: 80 OSA patients and 37 healthy volunteers were enrolled in the study. SCORE2 and SCORE 2 OP regional risk charts (validated algorithms to predict the 10-year risk of first-onset CVD) were used for the analysis of CVR. Two-dimensional echocardiography was performed on all patients and epicardial fat thickness was measured. VCAM-1 and ICAM-1 serum levels were assessed in all patients. (3) Results: OSA patients were classified as being at high CVR, regardless of the type of score achieved. Increased EFT was observed in the OSA group. VCAM-1 was associated with a high CVR in OSA patients, but no significant correlation was observed between adhesion molecules and epicardial fat thickness. (4) Conclusions: OSA patients have a high CVR according to the SCORE 2 and SCORE 2OP risk scores. VCAM-1 may be associated with a high CVR in OSA patients. Extending conventional risk stratification scores by adding other potential biomarkers improves the risk stratification and guide treatment eligibility for CVD prevention in the OSA population.
(1) 背景：尽管阻塞性睡眠呼吸暂停（OSA）与心血管疾病发病率增加相关，但OSA与心血管疾病（CVD）之间的联系尚未完全阐明。因此，我们旨在使用SCORE 2和老年人SCORE 2（SCORE 2OP）评估心血管风险（CVR），并评估内皮生物标志物血管细胞黏附分子-1（VCAM-1）、细胞间黏附分子-1（ICAM-1）、心外膜脂肪与睡眠研究参数之间的关联，以改进当前临床实践并更好地了解OSA患者的短期和长期CVR。(2) 方法：80例OSA患者和37名健康志愿者纳入本研究。使用SCORE2和SCORE 2 OP区域风险图表（用于预测首次发生CVD的10年风险的经过验证的算法）分析CVR。对所有患者进行二维超声心动图检查并测量心外膜脂肪厚度。评估所有患者的VCAM-1和ICAM-1血清水平。(3) 结果：无论获得何种评分类型，OSA患者均被归类为高CVR。在OSA组中观察到心外膜脂肪厚度增加。VCAM-1与OSA患者的高CVR相关，但未观察到黏附分子与心外膜脂肪厚度之间存在显著相关性。(4) 结论：根据SCORE 2和SCORE 2OP风险评分，OSA患者具有高CVR。VCAM-1可能与OSA患者的高CVR相关。通过添加其他潜在生物标志物扩展传统风险分层评分可改善风险分层，并指导OSA人群预防CVD的治疗资格。
