Bae Sijeong, Kwon Hwang, Yoon Hyemin, Park Miseon, Kim Hye-Ryun, Song Haengseok, Hong Kwonho, Choi Youngsok
Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
Fertility Center of CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do 13496, Republic of Korea.
Biochem Biophys Res Commun. 2016 Apr 8;472(3):489-95. doi: 10.1016/j.bbrc.2016.02.116. Epub 2016 Mar 3.
The sine oculis homeobox 1 (SIX1) is a member of the Six gene family. SIX1 is involved in tissue development by regulating proliferation, apoptosis, and differentiation. However, function of SIX1 in the uterus remains unknown. Here, we found that Six1 expression is regulated along the estrous cycle in mouse uterus. Six1 expression was significantly increased at estrus stage and decreased at the rest of stages. SIX1 is detected in the luminal and glandular epithelium of uterine endometrium at the estrus stage. Estrogen injection increased Six1 expression in the ovariectomized mouse uterus, whereas progesterone had no effect on its expression. Estrogen receptor antagonist inhibited estrogen-induced Six1 expression. Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle. These results will give us a better understanding of uterine biology.
正弦眼同源盒1（SIX1）是Six基因家族的成员。SIX1通过调节增殖、凋亡和分化参与组织发育。然而，SIX1在子宫中的功能尚不清楚。在此，我们发现Six1在小鼠子宫中的表达随发情周期而受到调节。Six1在发情期表达显著增加，在其他阶段表达降低。在发情期，SIX1在子宫内膜的腔上皮和腺上皮中被检测到。注射雌激素可增加去卵巢小鼠子宫中Six1的表达，而孕酮对其表达无影响。雌激素受体拮抗剂可抑制雌激素诱导的Six1表达。我们的研究结果表明，SIX1可能作为一个重要的调节因子，在发情周期中响应雌激素水平来协调子宫内膜的动态变化。这些结果将有助于我们更好地理解子宫生物学。
