骨骼肌细胞内脂质代谢与胰岛素抵抗。
Skeletal intramyocellular lipid metabolism and insulin resistance.
作者信息
Li Yiran, Xu Shimeng, Zhang Xuelin, Yi Zongchun, Cichello Simon
机构信息
Department of Biological Science and Biotechnology, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191 China ; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China ; University of Chinese Academy of Sciences, Beijing, 100049 China.
出版信息
Biophys Rep. 2015;1:90-98. doi: 10.1007/s41048-015-0013-0. Epub 2015 Oct 23.
Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal muscle, is different from other IMCLs, as it is stored in lipid droplets and plays a pivotal role in skeletal muscle energy homeostasis. This review discusses the association of FFA-induced ectopic lipid accumulation and IR, with specific emphasis on the relationship between IMCL/IMTG metabolism and IR.
储存在骨骼肌细胞中的脂质被称为肌内脂质（IMCL）。涉及IMCL及其致病因素循环游离脂肪酸（FFA）的紊乱会引发毒性状态，并最终导致肌肉组织中的胰岛素抵抗（IR）。另一方面，肌内甘油三酯（IMTG）是IMCL中最丰富的成分，也是活跃骨骼肌的重要能量来源，它与其他IMCL不同，因为它储存在脂滴中，并在骨骼肌能量稳态中起关键作用。本综述讨论了FFA诱导的异位脂质积累与IR的关联，特别强调了IMCL/IMTG代谢与IR之间的关系。
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