血浆神经酰胺靶向2型糖尿病中的骨骼肌。 - Suppr

Plasma ceramides target skeletal muscle in type 2 diabetes.

作者信息

Kirwan John P

机构信息

Metabolic Translational Research Center, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio, USA.

出版信息

Diabetes. 2013 Feb;62(2):352-4. doi: 10.2337/db12-1427.

DOI:10.2337/db12-1427

PMID:23349544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3554378/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6bd/3554378/9bec77825234/352fig1.jpg

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Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients.

Obesity (Silver Spring). 2011 Nov;19(11):2235-40. doi: 10.1038/oby.2011.107. Epub 2011 May 5.

Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content.

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Curr Opin Lipidol. 2009 Oct;20(5):363-9. doi: 10.1097/MOL.0b013e32832fa58d.

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance.

Diabetes. 2009 Feb;58(2):337-43. doi: 10.2337/db08-1228. Epub 2008 Nov 13.

Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry.

J Lipid Res. 2009 Mar;50(3):574-585. doi: 10.1194/jlr.D800028-JLR200. Epub 2008 Oct 1.

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Plasma ceramides target skeletal muscle in type 2 diabetes.

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