Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bioessays. 2023 Dec;45(12):e2300157. doi: 10.1002/bies.202300157. Epub 2023 Oct 18.
Dysregulation of lipid metabolism is a commonly observed feature associated with metabolic syndrome and leads to the development of negative health outcomes such as obesity, diabetes mellitus, non-alcoholic fatty liver disease, or atherosclerosis. Time-restricted feeding/eating (TRF/TRE), an emerging dietary intervention, has been shown to promote pleiotropic health benefits including the alteration of diurnal expression of genes associated with lipid metabolism, as well as levels of lipid species. Although TRF likely induces a response in multiple organs leading to the modulation of lipid metabolism, a majority of the studies related to TRF effects on lipids have focused only on individual tissues, and furthermore there is a lack of insight into potential underlying mechanisms. In this review, we summarize the current insights regarding TRF effects on lipid metabolism and the potential mechanisms in adipose tissue, liver, skeletal muscle, and heart, and conclude by outlining possible avenues for future exploration.
脂质代谢失调是与代谢综合征相关的常见特征，可导致肥胖、糖尿病、非酒精性脂肪肝或动脉粥样硬化等负面健康后果的发生。限时进食/摄食（TRF/TRE）作为一种新兴的饮食干预措施，已被证明具有多种健康益处，包括改变与脂质代谢相关的基因的昼夜表达以及脂质种类的水平。虽然 TRF 可能会引发多个器官的反应，从而调节脂质代谢，但大多数关于 TRF 对脂质影响的研究仅集中在单个组织上，而且对于潜在的机制还缺乏深入的了解。在这篇综述中，我们总结了目前关于 TRF 对脂肪组织、肝脏、骨骼肌和心脏中脂质代谢的影响及其潜在机制的研究进展，并概述了未来可能的探索途径。
