Tănăseanu S, Purice S
N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.
Med Interne. 1989 Jul-Sep;27(3):167-83.
The systemic vasculitides include a heterogenous group of diseases, characterized by inflammatory and necrotic lesions of the vessel walls, with subsequent ischemic changes in different organs. Various factors are incriminated in the vasculitides etiology, despite the fact that, in most of the cases, the etiologic agents are unknown. The pathogenic mechanisms are generally mediated through circulant immune complexes, which induce the inflammatory reaction at the vessel wall site, accompanied by complex immune reactions. A classification of vasculitides should take into account the type of the injured vessel, the elements of the inflammatory infiltrate and the triggering pathogenic mechanisms. The definition and monitoring of the therapeutic regimen are difficult but, generally, the main elements of medication are represented by corticosteroid and cytotoxic drugs.
系统性血管炎包括一组异质性疾病，其特征为血管壁的炎症性和坏死性病变，随后不同器官出现缺血性改变。尽管在大多数情况下病因不明，但多种因素被认为与血管炎的病因有关。致病机制通常由循环免疫复合物介导，这些复合物在血管壁部位引发炎症反应，并伴有复杂的免疫反应。血管炎的分类应考虑受损血管的类型、炎症浸润成分和触发致病机制。治疗方案的定义和监测很困难，但一般来说，药物治疗的主要成分是皮质类固醇和细胞毒性药物。
