Wei Kai, Yin Zhiwei, Xie Yuansheng
Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
Medical College, NanKai University, Tianjin, 300071, People's Republic of China.
J Nephrol. 2016 Jun;29(3):349-357. doi: 10.1007/s40620-016-0284-7. Epub 2016 Mar 4.
The relationship between the kidney and bone is highly complex, and the kidney plays an important role in the regulation of bone development and metabolism. The kidney is the major organ involved in the regulation of calcium and phosphate homeostasis, which is essential for bone mineralization and development. Many substances synthesized by the kidney, such as 1,25(OH)2D3, Klotho, bone morphogenetic protein-7, and erythropoietin, are involved in different stages of bone formation, remodeling and repair. In addition, some cytokines which can be affected by the kidney, such as osteoprotegerin, sclerostin, fibroblast growth factor -23 and parathyroid hormone, also play important roles in bone metabolism. In this paper, we summarize the possible effects of these kidney-related cytokines on bone and their possible mechanisms. Most of these cytokines can interact with one another, constituting an intricate network between the kidney and bone. Therefore, kidney diseases should be considered among patients presenting with osteodystrophy and disturbances in bone and mineral metabolism, and treatment for renal dysfunction may accelerate their recovery.
肾与骨的关系极为复杂，肾脏在骨发育和代谢的调节中发挥着重要作用。肾脏是参与钙和磷稳态调节的主要器官，而钙磷稳态对骨矿化和发育至关重要。肾脏合成的许多物质，如1,25(OH)2D3、Klotho、骨形态发生蛋白-7和促红细胞生成素，都参与骨形成、重塑和修复的不同阶段。此外，一些受肾脏影响的细胞因子，如骨保护素、硬化蛋白、成纤维细胞生长因子-23和甲状旁腺激素，在骨代谢中也发挥着重要作用。在本文中，我们总结了这些与肾脏相关的细胞因子对骨的可能影响及其可能机制。这些细胞因子大多可相互作用，在肾与骨之间构成一个错综复杂的网络。因此，对于出现骨营养不良以及骨和矿物质代谢紊乱的患者，应考虑肾脏疾病，对肾功能不全的治疗可能会加速其康复。
