钇-90肝动脉放射性栓塞：介入放射学临床综述及当前技术与个体化剂量测定
Yttrium-90 hepatic radioembolization: clinical review and current techniques in interventional radiology and personalized dosimetry.
作者信息
Tong Aaron K T, Kao Yung Hsiang, Too Chow Wei, Chin Kenneth F W, Ng David C E, Chow Pierce K H
机构信息
1 Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.
2 Department of Nuclear Medicine, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
出版信息
Br J Radiol. 2016 Jun;89(1062):20150943. doi: 10.1259/bjr.20150943. Epub 2016 Mar 24.
Abstract
In recent years, yttrium-90 ((90)Y) microsphere radioembolization has been establishing itself as a safe and efficacious treatment for both primary and metastatic liver cancers. This extends to both first-line therapies as well as in the salvage setting. In addition, radioembolization appears efficacious for patients with portal vein thrombosis, which is currently a contraindication for surgery, transplantation and transarterial chemoembolization. This article reviews the efficacy and expanding use of (90)Y microsphere radioembolization with an added emphasis on recent advances in personalized dosimetry and interventional radiology techniques. Directions for future research into combination therapies with radioembolization and expansion into sites other than the liver are also explored.
摘要
近年来，钇-90（90Y）微球放射性栓塞已成为治疗原发性和转移性肝癌的一种安全有效的方法。这适用于一线治疗以及挽救性治疗。此外，放射性栓塞对门静脉血栓形成患者似乎有效，而门静脉血栓形成目前是手术、移植和经动脉化疗栓塞的禁忌证。本文综述了90Y微球放射性栓塞的疗效及应用范围的扩大，特别强调了个性化剂量测定和介入放射学技术的最新进展。还探讨了放射性栓塞联合治疗的未来研究方向以及向肝脏以外部位扩展的可能性。
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1
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J Clin Oncol. 2016 May 20;34(15):1723-31. doi: 10.1200/JCO.2015.66.1181. Epub 2016 Feb 22.
2
Radioembolization of hepatocarcinoma with (90)Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology.用（90）Y玻璃微球进行肝癌的放射性栓塞：基于剂量学和放射生物学制定个体化治疗计划策略
Eur J Nucl Med Mol Imaging. 2015 Oct;42(11):1718-1738. doi: 10.1007/s00259-015-3068-8. Epub 2015 Jun 27.
3
Yttrium-90 microspheres: a review of its emerging clinical indications.钇-90微球：其新兴临床应用的综述
Liver Cancer. 2015 Mar;4(1):6-15. doi: 10.1159/000343876.
4
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Case Rep Oncol Med. 2015;2015:461823. doi: 10.1155/2015/461823. Epub 2015 Mar 16.
5
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J Gastrointest Oncol. 2015 Apr;6(2):134-42. doi: 10.3978/j.issn.2078-6891.2014.109.
6
Treatment algorithms for managing hepatocellular carcinoma.肝细胞癌的治疗算法
J Clin Exp Hepatol. 2014 Aug;4(Suppl 3):S80-9. doi: 10.1016/j.jceh.2014.05.004. Epub 2014 Jun 6.
7
Global cancer statistics, 2012.全球癌症统计数据，2012 年。
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8
Radioembolization dosimetry: the road ahead.放射性栓塞剂量测定：未来之路。
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Springerplus. 2014 Oct 10;3:595. doi: 10.1186/2193-1801-3-595. eCollection 2014.
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