Hamidi Sarah, Mahvash Armeen, Hu Mimi I
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX 77030, USA.
Department of Interventional Radiology, The University of Texas MD Anderson Cancer, Houston, TX 77030, USA.
JCEM Case Rep. 2024 Jul 29;2(8):luae103. doi: 10.1210/jcemcr/luae103. eCollection 2024 Aug.
Medullary thyroid carcinoma (MTC) can often have an indolent course despite distant metastatic disease. Additionally, given that metastatic MTC is incurable and systemic therapies have non-negligeable toxicities, localized treatments are often favored in presence of oligo-progressive disease. Transarterial radioembolization (TARE) with yttrium-90 (Y90) has emerged as a safe and efficacious treatment for nonresectable primary and metastatic liver tumors, yet data supporting its use in metastatic MTC are limited. We present the case of a patient with hereditary MTC and large bilobar liver metastases who demonstrated tumor response and resolution of their paraneoplastic diarrhea following TARE with Y90 microspheres.
甲状腺髓样癌（MTC）尽管存在远处转移疾病，但通常病程较为隐匿。此外，鉴于转移性MTC无法治愈且全身治疗存在不可忽视的毒性，在出现寡进展性疾病时，局部治疗往往更受青睐。钇-90（Y90）经动脉放射性栓塞（TARE）已成为不可切除的原发性和转移性肝肿瘤的一种安全有效的治疗方法，但支持其用于转移性MTC的数据有限。我们报告了一例患有遗传性MTC且有双侧大肝转移的患者，该患者在接受Y90微球TARE治疗后显示出肿瘤反应并缓解了副肿瘤性腹泻。
