Wdowiak Kamil, Spychałowicz Wojciech, Fajkis Marcin, Wojnar Jerzy
Katedra i Klinika Chorób Wewnętrznych i Chemioterapii Onkologicznej Śląskiego Uniwersytetu Medycznego w Katowicach.
Postepy Hig Med Dosw (Online). 2016 Feb 14;70:95-103. doi: 10.5604/17322693.1194808.
Galectins are a family of lectins characterized by an affinity for β-galactosides through the carbohydrate recognition domain (CRD). The extracellular and intracellular presence of Galectins has been described. Their activity and functions are mainly attributed to cell type. The tumor microenviroment is a complex milieu connected with immunosupression, angiogenesis and hypoxic compartments. The studies of interactions between Glycans-Lectins are highly advanced and promising. We are not able to explain the pathogenesis of many diseases only by protein-protein interactions, that is why in these studies is a chance to find a new therapeutic targets. Galectins play a fundametal functions in tumor growth and progression, angiogenesis, adhesion, tumor immune-escape. They are also active in inflammation, fibrosis, organogenesis and immunological functions. The most known Galectin is Gal-3. Depending on the localization Gal-3 may exhibit either pro-apoptotic or anti-apoptotic activity. This publication presents role of Galectins in hematological malignancies and shows potencial prognostoic value and new therapeutic possibilities.
半乳糖凝集素是一类凝集素，其特征是通过碳水化合物识别结构域（CRD）对β-半乳糖苷具有亲和力。半乳糖凝集素在细胞外和细胞内的存在已有描述。它们的活性和功能主要归因于细胞类型。肿瘤微环境是一个与免疫抑制、血管生成和缺氧区室相关的复杂环境。聚糖-凝集素之间相互作用的研究非常先进且前景广阔。仅通过蛋白质-蛋白质相互作用，我们无法解释许多疾病的发病机制，这就是为什么在这些研究中有机会找到新的治疗靶点。半乳糖凝集素在肿瘤生长、进展、血管生成、黏附、肿瘤免疫逃逸中发挥着重要作用。它们在炎症、纤维化、器官发生和免疫功能中也具有活性。最知名的半乳糖凝集素是Gal-3。根据定位不同，Gal-3可能表现出促凋亡或抗凋亡活性。本出版物介绍了半乳糖凝集素在血液系统恶性肿瘤中的作用，并展示了其潜在的预后价值和新的治疗可能性。
