Kierkegaard Marie, Lundberg Ingrid E, Olsson Tomas, Johansson Sverker, Ygberg Sofia, Opava Christina, Holmqvist Lotta Widén, Piehl Fredrik
Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, 23 100, S-141 83 Huddinge, Sweden; Department of Physiotherapy, A6:U1, Karolinska University Hospital, S-171 76 Stockholm, Sweden.
Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, S-171 76, Stockholm, Sweden.
J Neurol Sci. 2016 Mar 15;362:251-7. doi: 10.1016/j.jns.2016.01.063. Epub 2016 Feb 3.
High-intensity resistance training is unexplored in people with multiple sclerosis.
To evaluate effects of high-intensity resistance training on immune markers and on measures of mood, fatigue, health-related quality of life, muscle strength, walking and cognition. Further, to describe participants' opinion and perceived changes of the training.
Twenty patients with relapsing-remitting multiple sclerosis performed high-intensity resistance training at an intensity of 80% of one-repetition maximum, twice a week for 12 weeks. Blood and optional cerebrospinal fluid samples, and data on secondary outcome measures were collected before and after intervention. A study-specific questionnaire was used for capturing participants' opinion.
Seventeen participants completed the study. Plasma cytokine levels of tumor necrosis factor were significantly decreased post-intervention (p=0.001). Exploratory cytokine analyses in cerebrospinal fluid (n=8) did not reveal major changes. Significant and clinically important improvements were found in fatigue (p=0.001) and health-related quality of life (p=0.004). Measures of mood (p=0.002), muscle strength (p ≤ 0.001), walking speed (p=0.013) and cognition (p=0.04) were also improved. A majority of participants evaluated the training as very good and perceived changes to the better.
High-intensity resistance training in persons with relapsing remitting multiple sclerosis with low disability had positive effects on peripheral pro-inflammatory cytokine levels, led to clinically relevant improvements in measures of fatigue and health-related quality of life, and was well tolerated. These results provide a basis for a larger randomized trial.
高强度抗阻训练在多发性硬化症患者中尚未得到充分研究。
评估高强度抗阻训练对免疫标志物、情绪、疲劳、健康相关生活质量、肌肉力量、步行能力和认知的影响。此外，描述参与者对训练的看法和感知到的变化。
20例复发缓解型多发性硬化症患者以一次最大重复量的80%强度进行高强度抗阻训练，每周两次，共12周。在干预前后收集血液和可选的脑脊液样本以及次要结局指标数据。使用一项专门的研究问卷来获取参与者的意见。
17名参与者完成了研究。干预后血浆肿瘤坏死因子细胞因子水平显著降低（p = 0.001）。脑脊液（n = 8）中的探索性细胞因子分析未发现重大变化。在疲劳（p = 0.001）和健康相关生活质量（p = 0.004）方面发现了显著且具有临床意义的改善。情绪（p = 0.002）、肌肉力量（p≤0.001）、步行速度（p = 0.013）和认知（p = 0.04）指标也有所改善。大多数参与者将训练评价为非常好，并感觉有向好的变化。
对低残疾程度的复发缓解型多发性硬化症患者进行高强度抗阻训练对外周促炎细胞因子水平有积极影响，在疲劳和健康相关生活质量指标方面带来了临床相关的改善，并且耐受性良好。这些结果为一项更大规模的随机试验提供了依据。
