Caravaggio Fernando, Fervaha Gagan, Chung Jun Ku, Gerretsen Philip, Nakajima Shinichiro, Plitman Eric, Iwata Yusuke, Wilson Alan, Graff-Guerrero Ariel
Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8; Institute of Medical Science, University of Toronto, 2374 Medical Sciences Building, 1 King׳s College Circle, Toronto, Ontario, Canada M5S 1A8.
Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8; Institute of Medical Science, University of Toronto, 2374 Medical Sciences Building, 1 King׳s College Circle, Toronto, Ontario, Canada M5S 1A8; Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8.
Eur Neuropsychopharmacol. 2016 Apr;26(4):644-52. doi: 10.1016/j.euroneuro.2016.02.010. Epub 2016 Feb 27.
While several studies have examined how particular personality traits are related to dopamine D2/3 receptor (D2/3R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D2/3R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D2/3R availability measured with [(11)C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D2/3R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D2/3R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D2/3R availability in these regions survived correction for multiple comparisons (p-threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D2/3R availability in different striatal sub-regions.
虽然已有多项研究探讨了特定人格特质与人类纹状体中多巴胺D2/3受体（D2/3R）可用性之间的关系，但很少有研究报告在同一人群中测量的多种特质与不同纹状体亚区域的D2/3R可用性之间存在怎样的差异关系。我们研究了使用卡罗林斯卡人格量表测量的人格特质与30名健康人使用[（11）C] - 雷氯必利测量的纹状体D2/3R可用性之间的关系。基于以往文献，假设五种人格特质最有可能与D2/3R可用性相关：冲动性、避免单调、超脱、社会期望和社交性。我们发现自我报告的冲动性与腹侧纹状体和苍白球中的D2/3R可用性呈负相关。在控制年龄和性别后，避免单调也与腹侧纹状体和苍白球中的D2/3R可用性呈负相关。社交性与腹侧纹状体和壳核中的D2/3R可用性呈正相关。在控制年龄和性别后，这些区域中社交性与D2/3R可用性之间的关系在多重比较校正后仍然显著（p阈值 = 0.003）。因此，在同一人群中，不同人格特质与不同纹状体亚区域的体内D2/3R可用性存在差异关系。
