Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, China.
Brain Behav. 2020 Dec;10(12):e01897. doi: 10.1002/brb3.1897. Epub 2020 Oct 17.
Cloninger developed the three-dimensional personality theory and Tridimensional Personality Questionnaire (TPQ), which shows that some dimensions of personality traits are heritable and related to neurotransmitters including dopamine. glutathione peroxidase 1 (GPx1) plays an important role in metabolic dopamine change and closely relates to neurological and psychiatric disorders. The impact of GPx-1 polymorphisms has been rarely explored in the field of personality traits. We decide to explore the relationships between them in healthy Chinese-Han subjects by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
In our study, 493 healthy Chinese-Han participants (male = 234, female = 259) were recruited. 2 ml of EDTA-treated blood from each volunteer was taken; meanwhile, personality traits were assessed by TPQ. We detected the genotypes of selected two polymorphisms through PCR-RFLP after extracting DNA. Finally, the association between different genotypes and TPQ scores was performed using SPSS, p < .05 is seen as significant statistical significance.
Our data found a correlation between rs1800668 and novelty seeking (NS) subscale NS2 (X = 7.392, p = .025). While the results showed the rs1050450 was significantly associated with NS4 (X = 6.059, p = .048). Regarding sex stratification, there was a significant difference in the NS2 score (X = 8.232, p = .016) among women for rs1800668. No sex effect was observed for either genotype for rs1050450.
GPx-1polymorphism is related to personality traits in healthy Chinese-Han subjects. Our results suggested that GPx-1 may be involved in the biological mechanisms and be a potential gene that influenced personality.
Cloninger 提出了三维人格理论和三维人格问卷（TPQ），表明人格特质的某些维度是可遗传的，与包括多巴胺在内的神经递质有关。谷胱甘肽过氧化物酶 1（GPx1）在代谢多巴胺变化中起重要作用，与神经和精神疾病密切相关。GPx-1 多态性在人格特质领域的影响很少被探索。我们决定通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）在健康的汉族中国人群中探索它们之间的关系。
在我们的研究中，招募了 493 名健康的汉族参与者（男性=234，女性=259）。从每个志愿者采集 2ml EDTA 处理的血液；同时，通过 TPQ 评估人格特质。提取 DNA 后，我们通过 PCR-RFLP 检测了所选两个多态性的基因型。最后，使用 SPSS 分析不同基因型与 TPQ 评分之间的关系，p<0.05 被视为具有显著统计学意义。
我们的数据发现 rs1800668 与新奇寻求（NS）亚量表 NS2 之间存在相关性（X=7.392，p=0.025）。而 rs1050450 与 NS4 显著相关（X=6.059，p=0.048）。关于性别分层，rs1800668 在女性的 NS2 评分中存在显著差异（X=8.232，p=0.016）。对于 rs1050450，两种基因型均未观察到性别效应。
GPx-1 多态性与健康汉族人群的人格特质有关。我们的结果表明，GPx-1 可能参与了生物学机制，并可能是影响人格的潜在基因。
