De Mello Walmor C
School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936-5067, USA.
Peptides. 2016 Apr;78:87-90. doi: 10.1016/j.peptides.2016.02.006. Epub 2016 Mar 2.
The influence of intracellular angiotensin II on the regulation of potassium current and membrane potential of smooth muscle cells of mesenteric arteries and its relevance for the regulation of vascular tone was reviewed. The presence of components of the renin angiotensin system (RAS) in different cells of the cardiovascular system, was discussed including their presence in the nuclei and mitochondria. Emphasis was given to the opposite effects of intracellular and extracellular angiotensin II (Ang II) on the regulation of potassium current, membrane potential and contractility of vascular resistance vessels and its implication to vascular physiology and pathology and the possible role of epigenetic factors on the expression of angiotensin II (Ang II) and renin in vascular resistance vessels as well as its possible pathophysiological role in hypertension and other cardiovascular diseases.
本文综述了细胞内血管紧张素II对肠系膜动脉平滑肌细胞钾电流和膜电位调节的影响及其与血管张力调节的相关性。讨论了肾素血管紧张素系统（RAS）在心血管系统不同细胞中的存在情况，包括其在细胞核和线粒体中的存在。重点阐述了细胞内和细胞外血管紧张素II（Ang II）对血管阻力血管钾电流、膜电位和收缩性调节的相反作用及其对血管生理和病理的影响，以及表观遗传因素对血管阻力血管中血管紧张素II（Ang II）和肾素表达的可能作用及其在高血压和其他心血管疾病中的可能病理生理作用。
