一种用于快速灵敏检测无机叠氮化物的无金属开启型荧光探针。
A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides.
作者信息
Wang Ke, Friscourt Frédéric, Dai Chaofeng, Wang Lifang, Zheng Yueqin, Boons Geert-Jan, Wang Siming, Wang Binghe
机构信息
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA.
Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
出版信息
Bioorg Med Chem Lett. 2016 Apr 1;26(7):1651-4. doi: 10.1016/j.bmcl.2016.02.069. Epub 2016 Feb 23.
Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10μM.
叠氮化钠有毒，广泛应用于农业、商业产品及研究实验室。因此，它是一个重大的环境问题，需要开发一种快速检测方法。本文描述了一种荧光二苄基环辛炔衍生物（Fl-DIBO），作为一种通过应变促进的叠氮化物-炔烃环加成反应（SPAAC）快速检测无机叠氮化物的荧光探针。与其他常见阴离子相比，Fl-DIBO对NaN3具有高度选择性，具有良好的灵敏度，检测限为10μM。
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