Department of Anaesthesia, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.
Department of Anaesthesiology, Toho University, School of Medicine, Tokyo, Japan.
Anaesthesia. 2016 May;71(5):544-9. doi: 10.1111/anae.13414. Epub 2016 Mar 4.
Levobupivacaine is commonly used as the local anaesthetic of choice in peripheral nerve blocks, but its pharmacokinetics have not been fully investigated. We compared the changes in plasma concentrations of levobupivacaine following transversus abdominis plane block and rectus sheath block. Fifty woman undergoing laparoscopy were randomly allocated to receive either a transversus abdominis plane block or an rectus sheath block. In both groups, 2.5 mg.kg(-1) levobupivacaine was administered, and blood samples were obtained 15 min, 30 min, 60 min and 120 min after injection. The mean maximum plasma concentration (Cmax) and mean time to reach Cmax (Tmax) as determined by non-linear regression analysis were 1.05 μg.ml(-1) and 32.4 min in the transversus abdominis plane group and 0.95 μg.ml(-1) and 60.9 min in the rectus sheath group, respectively. The plasma concentration of levobupivacaine peaked earlier in the transversus abdominis plane group than in the rectus sheath group and the maximum plasma concentration depended on the dose administered but not the procedure.
左旋布比卡因常用于外周神经阻滞的局部麻醉剂，但尚未充分研究其药代动力学。我们比较了腹横肌平面阻滞和腹直肌鞘阻滞后左旋布比卡因血浆浓度的变化。50 例行腹腔镜手术的女性随机分为接受腹横肌平面阻滞或腹直肌鞘阻滞。两组均给予 2.5mg.kg(-1)左旋布比卡因，注射后 15 分钟、30 分钟、60 分钟和 120 分钟采集血样。采用非线性回归分析确定的平均最大血浆浓度（Cmax）和达到 Cmax 的平均时间（Tmax）分别为腹横肌平面组 1.05μg.ml(-1)和 32.4 分钟，腹直肌鞘组 0.95μg.ml(-1)和 60.9 分钟。腹横肌平面组的左旋布比卡因血浆浓度峰值早于腹直肌鞘组，最大血浆浓度取决于给药剂量而不是手术。
