Bedford Peter G C
Professor Emeritus of Veterinary Ophthalmology, Royal Veterinary College, London, UK.
Ophthalmology Referrals, 25, Great North Road, Brookmans Park, Herts. AL9 6LB, North Mymms, Hatfield, UK.
Vet Ophthalmol. 2017 Mar;20(2):98-102. doi: 10.1111/vop.12369. Epub 2016 Mar 4.
To report the prevalence and clinical characteristics of an open-angle glaucoma in Petit Basset Griffon Vendeen (PBGV) dogs in the United Kingdom (UK).
At breed society clinics extending over a 6-year period, 366 dogs of varying ages and both sexes were clinically examined for signs of glaucoma using slit-lamp biomicroscopy, indirect and direct ophthalmoscopy, tonometry, and gonioscopy.
The prevalence of glaucoma was 10.4% (38 dogs). Clinical signs of the disease presented from 3 years of age onwards, the commonest initial feature being the elevation of intraocular pressure (IOP) in 15 dogs (39.4%). In addition to elevated IOP, another 13 dogs (34.2%) presented with other features of glaucoma, some with lens subluxation and globe enlargement and all with possible or known vision defects. In the remaining 10 dogs (26.3%), phacodonesis or lens subluxation was observed before subsequent elevation of IOP.
High prevalence and similarity to the primary open-angle glaucoma (POAG) seen in the Beagle and Elkhound breeds indicate that an open-angle glaucoma is present in the PBGV in the UK and that this disease may be genetically determined in this breed. Although increased IOP is the commonest early diagnostic feature, lens instability prior to an increase in IOP may be part of the clinical picture.
报告英国小猎兔犬（PBGV）中开角型青光眼的患病率及临床特征。
在为期6年的品种协会诊所中，对366只不同年龄和性别的犬进行了临床检查，使用裂隙灯生物显微镜检查、间接和直接检眼镜检查、眼压测量和前房角镜检查来检测青光眼迹象。
青光眼患病率为10.4%（38只犬）。该病的临床症状从3岁开始出现，最常见的初始特征是15只犬（39.4%）眼压升高。除眼压升高外，另有13只犬（34.2%）出现青光眼的其他特征，部分伴有晶状体半脱位和眼球增大，且均有可能或已知的视力缺陷。在其余10只犬（26.3%）中，在眼压随后升高之前观察到晶状体震颤或晶状体半脱位。
高患病率以及与比格犬和挪威猎麋犬中所见原发性开角型青光眼（POAG）的相似性表明，英国的PBGV存在开角型青光眼，且该疾病可能在该品种中由基因决定。虽然眼压升高是最常见的早期诊断特征，但在眼压升高之前晶状体不稳定可能是临床症状的一部分。
