Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran.
J Med Virol. 2016 Sep;88(9):1622-7. doi: 10.1002/jmv.24509. Epub 2016 Mar 15.
Cytomegalovirus (CMV) is one of the most important infections in renal transplant recipients. Kidney transplant is the last hope for the patients with end stage renal diseases. Cytomegalovirus infection can threaten patients and graft survival after transplantation. Four hundred and thirty-four renal transplant recipients contributed to this study. PCR and RFLP analyses were performed in order to determine CMV viremia and its genotypes. CMV viremia was detected in 68 (15.9%) recipients. The mean post-transplantation time in our recipients was 50 months, ranging from 1 to 354 months. Viremia was detected in 31.2%, 30.7%, 17.5%, 10.2%, and 6.4% of the recipients in 0-3, 4-6, 7-12, 13-24, and more than 24 months post-transplantation, respectively. The distribution of gB1, gB2, gB3, and gB4 genotypes was detected as 26.5%, 20.5%, 17.6%, and 5.9%, respectively. Mixed genotype infection was observed in 29.4% of the recipients. Incidence of viremia was higher in the first 6 months after the transplantation compared with the later stages. Moreover, CMV gB1 and mixed genotype infection were more common in our recipients. J. Med. Virol. 88:1622-1627, 2016. © 2016 Wiley Periodicals, Inc.
巨细胞病毒（CMV）是肾移植受者最重要的感染之一。肾移植是终末期肾病患者的最后希望。CMV 感染会威胁移植后的患者和移植物的存活。本研究共有 434 例肾移植受者。为了确定 CMV 病毒血症及其基因型，进行了 PCR 和 RFLP 分析。在 68 名（15.9%）受者中检测到 CMV 病毒血症。我们受者的平均移植后时间为 50 个月，范围为 1 至 354 个月。在移植后 0-3、4-6、7-12、13-24 和>24 个月的受者中，病毒血症分别在 31.2%、30.7%、17.5%、10.2%和 6.4%的受者中检测到。gB1、gB2、gB3 和 gB4 基因型的分布分别为 26.5%、20.5%、17.6%和 5.9%。在 29.4%的受者中观察到混合基因型感染。与后期相比，移植后前 6 个月病毒血症的发生率更高。此外，CMV gB1 和混合基因型感染在我们的受者中更为常见。J. Med. Virol. 88:1622-1627, 2016. © 2016 Wiley Periodicals, Inc.
