Lim Seong-In, Song Jae-Young, Kim Jaejo, Hyun Bang-Hun, Kim Ha-Young, Cho In-Soo, Kim Byounghan, Woo Gye-Hyeong, Lee Jung-Bok, An Dong-Jun
Animal and Plant Quarantine Agency (QIA), 175 Anayangro Manangu Anyangsi, Gyeonggido 430-824, South Korea.
Department of Clinical Laboratory Science, Semyung University, Semyung-ro 65, Jecheon, Chungbuk 390-711, South Korea.
Vaccine. 2016 Apr 12;34(17):2021-6. doi: 10.1016/j.vaccine.2016.02.062. Epub 2016 Mar 3.
The present study aimed to evaluate the safety of the classical swine fever virus (CSFV) vaccine strain LOM in pregnant sows. Pregnant sows with free CSFV antibody were inoculated with a commercial LOM vaccine during early pregnancy (day 38; n=3) or mid-pregnancy (days 49-59; n=11). In pregnant sows vaccinated during the early stages of gestation, abortion (day 109) was observed in one case, with two stillbirths and seven mummified fetuses. The viability of live-born piglets was 34.9% in sows vaccinated during mid-pregnancy compared with 81.8% in the control group. Post-mortem examination of the organs of the sows and piglets did not reveal any pathological lesions caused by CSFV; however, CSFV RNA was detected in the organs of several vaccinated sows and their litters. The LOM strain was transmitted from sows with free CSFV antibody to their fetus, but did not appear to induce immune tolerance in the offspring from vaccinated pregnant sows. Side effects were not observed in pregnant sows with antibody to the LOM strain: transmission from sow to their litters and stillbirth or mummified fetuses. The LOM strain may induce sterile immunity and provide rapid, long-lasting, and complete protection against CSFV; however, it should be contraindicated in pregnant sows due to potential adverse effects in pregnant sows with free CSFV antibody.
本研究旨在评估经典猪瘟病毒（CSFV）疫苗株LOM在妊娠母猪中的安全性。对CSFV抗体阴性的妊娠母猪在妊娠早期（第38天；n = 3）或妊娠中期（第49 - 59天；n = 11）接种市售LOM疫苗。在妊娠早期接种疫苗的妊娠母猪中，观察到1例流产（第109天），伴有2例死产和7例木乃伊化胎儿。妊娠中期接种疫苗的母猪所产活仔猪的存活率为34.9%，而对照组为81.8%。对母猪和仔猪的器官进行尸检未发现由CSFV引起的任何病理损伤；然而，在几只接种疫苗的母猪及其仔猪的器官中检测到了CSFV RNA。LOM株从CSFV抗体阴性的母猪传播至其胎儿，但似乎未在接种疫苗的妊娠母猪后代中诱导免疫耐受。在对LOM株有抗体的妊娠母猪中未观察到副作用：从母猪传播至其仔猪以及死产或木乃伊化胎儿。LOM株可能诱导无菌免疫并提供针对CSFV的快速、持久和完全保护；然而，由于对CSFV抗体阴性的妊娠母猪可能产生不良反应，应禁止在妊娠母猪中使用。
