Oliveira M, Malheiro F
Acta Med Port. 1989 Sep;Suppl 1:47S-50S.
The authors discuss the pathogenesis of glucose intolerance occurring in advanced age and the importance of peripheral insulin resistance due to deficiency of post receptor mechanisms. Prevalence of diabetes increases with age and its diagnosis should not be overlooked as it can cause considerable morbidity and mortality in this age group. Acute and chronic complications are discussed as well as the aggravating influence of coexistent pathology and its medication, and of social, environmental and economic factors. Therapeutic measures and desirable therapeutic goals are considered for this specific age group, taking into account the need for an individualised treatment and the priority of well being and safety over too strict control.
作者讨论了老年期糖耐量异常的发病机制以及受体后机制缺陷导致的外周胰岛素抵抗的重要性。糖尿病的患病率随年龄增长而增加，其诊断不应被忽视，因为它会在该年龄组中导致相当高的发病率和死亡率。文中讨论了急性和慢性并发症，以及并存疾病及其药物治疗、社会、环境和经济因素的加重影响。针对这一特定年龄组，考虑到个体化治疗的必要性以及健康和安全优先于过于严格的控制，探讨了治疗措施和理想的治疗目标。
