Zagólski Olaf, Gajda Mariusz, Stręk Paweł, Kozlowski Michael John, Gądek Artur, Nyzio Jerzy
St. John Grande's Hospital, ENT Day Surgery Department, Kraków, Poland.
Jagiellonian University Medical College, Department of Histology, Kraków, Poland.
Braz J Otorhinolaryngol. 2016 Sep-Oct;82(5):589-95. doi: 10.1016/j.bjorl.2015.11.010. Epub 2016 Feb 16.
Intense pain is one of the most important postoperative complaints after tonsillectomy. It is often described by patients as comparable to the pain that accompanies an acute tonsillitis. Although recurrent tonsillitis is the most frequent indication for surgery, many tonsillectomies are performed due to other indications and these patients may be unfamiliar with such pain.
To verify whether individuals with recurrent tonsillitis experience different post-tonsillectomy pain intensity than those with other indications for surgery, with no history of episodes of acute tonsillitis.
A total of 61 tonsillectomies were performed under general anesthesia, using a potassium titanyl phosphate (KTP) laser (to eliminate the potential influence on the study results of forceful dissection of fibrotic tonsils in patients with history of recurrent tonsillitis) and multiple ligations of blood vessels within the tonsillar beds. The patients received 37.5mg Tramadoli hydrochloridum+325mg Paracetamol tablets for 10 days. Postoperative variables included the duration of hospital stay, postoperative hemorrhage and readmission rate. The patients reported pain intensity on consecutive days, pain duration, weight loss on postoperative day 10, character, intensity and duration of swallowing difficulties, and the need for additional doses of painkillers. Healing was also assessed. Capsular nerve fibers were histologically examined in the resected tonsils by immunostainings for general and sensory markers.
Indications for the surgery were: recurrent acute tonsillitis (34 patients), no history of recurrent tonsillitis: focus tonsil (20) and intense malodour (7). Pain intensity on postoperative days 3-4 and incidence of readmissions due to dehydration were significantly higher in the group with no history of recurrent tonsillitis. No significant differences in relative densities of protein gene product (PGP) 9.5- and calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers were observed.
Patients with recurrent tonsillitis qualified for tonsillectomy reported lower pain intensity than those without recurrent tonsillitis and the pain scores were unrelated to nerve fibers density.
剧烈疼痛是扁桃体切除术后最重要的术后主诉之一。患者常称其疼痛程度堪比急性扁桃体炎时的疼痛。尽管复发性扁桃体炎是最常见的手术指征,但许多扁桃体切除术是因其他指征进行的,这些患者可能对这种疼痛并不熟悉。
验证复发性扁桃体炎患者与无急性扁桃体炎发作史且因其他手术指征接受扁桃体切除术的患者相比,扁桃体切除术后的疼痛强度是否不同。
在全身麻醉下共进行了61例扁桃体切除术,使用磷酸钛钾(KTP)激光(以消除复发性扁桃体炎病史患者中纤维化扁桃体强力剥离对研究结果的潜在影响)并对扁桃体床内血管进行多次结扎。患者服用37.5毫克盐酸曲马多+325毫克对乙酰氨基酚片,持续10天。术后变量包括住院时间、术后出血和再入院率。患者连续报告疼痛强度、疼痛持续时间、术后第10天体重减轻情况、吞咽困难的性质、强度和持续时间以及额外服用止痛药的需求。还评估了愈合情况。通过对一般和感觉标记物的免疫染色,对切除扁桃体中的包膜神经纤维进行组织学检查。
手术指征为:复发性急性扁桃体炎(34例患者),无复发性扁桃体炎病史:病灶扁桃体(20例)和严重口臭(7例)。无复发性扁桃体炎病史组术后第3 - 4天的疼痛强度和因脱水再入院的发生率显著更高。未观察到蛋白质基因产物(PGP)9.5和降钙素基因相关肽(CGRP)免疫反应性神经纤维的相对密度有显著差异。
符合扁桃体切除术条件的复发性扁桃体炎患者报告的疼痛强度低于无复发性扁桃体炎患者,且疼痛评分与神经纤维密度无关。