Zhu Mingxin, Li Man, Ye Dawei, Jiang Wei, Lei Ting, Shu Kai
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Neurosci Res. 2016 Aug;94(8):685-92. doi: 10.1002/jnr.23729. Epub 2016 Mar 6.
Parkinson's disease (PD) is one of the most common forms of neurodegenerative disease in the elderly population and is typically manifested by motor symptoms and nonmotor symptoms and signs. Nonmotor symptoms, such as sensory symptoms, have been regarded as the significant features of this disease. These symptoms often occur in early stages of PD and influence quality of life. However, researchers suggest that the sensory symptoms of PD are frequently unrecognized by clinicians and remain untreated. The disorders include pain, olfactory disturbance, and visual dysfunction input on the underlying sensory abnormality. This Review focuses on the clinical features, pathophysiological mechanisms, and treatment strategies for sensory symptoms of PD from both clinical studies and basic research, providing a comprehensive overview of the sensory symptoms in PD. © 2016 Wiley Periodicals, Inc.
帕金森病（PD）是老年人群中最常见的神经退行性疾病之一，通常表现为运动症状以及非运动症状和体征。非运动症状，如感觉症状，已被视为该疾病的显著特征。这些症状常出现在帕金森病的早期阶段，并影响生活质量。然而，研究人员表明，帕金森病的感觉症状常常未被临床医生识别且未得到治疗。这些病症包括疼痛、嗅觉障碍以及基于潜在感觉异常的视觉功能障碍。本综述从临床研究和基础研究两方面着重探讨帕金森病感觉症状的临床特征、病理生理机制及治疗策略，全面概述帕金森病中的感觉症状。© 2016威利期刊公司。
