Gazerani Parisa
Laboratory of Molecular Pharmacology, Department of Health Science & Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg East, Denmark.
Future Sci OA. 2020 Nov 30;7(2):FSO642. doi: 10.2144/fsoa-2020-0119.
Neurodegenerative diseases, including Parkinson's disease (PD), are increasing in the aging population. Crucially, neurodegeneration of dopaminergic neurons in PD is associated with chronic inflammation and glial activation. Besides this, bradykinesia, resting tremor, rigidity, sensory alteration, and cognitive and psychiatric impairments are also present in PD. Currently, no pharmacologically effective treatment alters the progression of the disease. Discovery and development of new treatment strategies remains a focus for ongoing investigations. For example, one approach is cell therapy to prevent dopaminergic neuronal loss or to slow PD progression. The neuroprotective role of a diverse range of natural products, including venoms from bees, scorpions, snakes and lizards, are also being tested in preclinical PD models and in humans. The main findings from recent studies that have investigated venoms as therapeutic options for PD are summarized in this special report.
包括帕金森病（PD）在内的神经退行性疾病在老龄化人口中呈上升趋势。至关重要的是，PD中多巴胺能神经元的神经退行性变与慢性炎症和神经胶质细胞激活有关。除此之外，PD还存在运动迟缓、静止性震颤、僵硬、感觉改变以及认知和精神障碍。目前，尚无药物能有效改变该疾病的进展。新治疗策略的发现和开发仍是正在进行的研究重点。例如，一种方法是细胞疗法，以防止多巴胺能神经元丢失或减缓PD进展。包括蜜蜂、蝎子、蛇和蜥蜴毒液在内的多种天然产物的神经保护作用也正在临床前PD模型和人体中进行测试。本特别报告总结了最近研究毒液作为PD治疗选择的主要发现。
