Nakasone Tasuku, Sugimoto Yumi, Kamei Chiaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University, 6-13-1, Yasuhigashi, Asaminami-Ku, Hiroshima 731-0153, Japan.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University, 6-13-1, Yasuhigashi, Asaminami-Ku, Hiroshima 731-0153, Japan.
Eur J Pharmacol. 2016 Apr 15;777:124-8. doi: 10.1016/j.ejphar.2016.03.005. Epub 2016 Mar 3.
In this study, we examined the interaction between histamine H1 receptor and μ-opioid receptor in scratching behavior in ICR mice. Both histamine and morphine caused scratching and simultaneous injection of histamine and morphine had an additive effect. Chlorpheniramine and naloxone inhibited histamine-induced scratching behavior. These two drugs also inhibited morphine-induced scratching behavior. Simultaneous injection of chlorpheniramine and naloxone caused a significant inhibition of histamine-induced scratching compared with separate injections. The same findings were also noted for morphine-induced scratching. These results strongly indicate a close relationship between histamine H1 receptor and μ-opioid receptor in scratching behavior in ICR mice.
