Tong Jianhua, Cheng Yu, Holzapfel Gerhard A
Shanghai East Hospital, Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, PR China.
Graz University of Technology, Institute of Biomechanics, Stremayrgasse 16-II, 8010 Graz, Austria.
J Biomech. 2016 Aug 16;49(12):2366-73. doi: 10.1016/j.jbiomech.2016.02.009. Epub 2016 Feb 12.
Arterial dissection involves a complex series of coupled biomechanical events. The past two decades have witnessed great advances in the understanding of the intrinsic mechanism for dissection initiation, and hence in the development of novel therapeutic strategies for surgical repair. This is due in part to the profound advancements in characterizing emerging behaviors of dissection using state-of-the-art tools in experimental and computational biomechanics. In addition, researchers have identified the important role of the microstructure in determining the tissue׳s fracture modality during dissection propagation. In this review article, we highlight a variety of approaches in terms of biomechanical measurements, computational modeling and histological/microstructural analysis used to characterize a dissection that propagates in healthy and diseased arteries. Notable findings with quantitative mechanical data are reviewed. We conclude by discussing some unsolved problems that are of interest for future research.
动脉夹层涉及一系列复杂的耦合生物力学事件。在过去的二十年里，人们对夹层起始的内在机制的理解取得了巨大进展，从而在手术修复的新型治疗策略的开发方面也取得了很大进展。部分原因是在实验和计算生物力学中使用先进工具来表征夹层的新出现行为方面取得了深刻进展。此外，研究人员已经确定了微观结构在夹层扩展过程中确定组织骨折方式方面的重要作用。在这篇综述文章中，我们重点介绍了用于表征在健康和患病动脉中传播的夹层的生物力学测量、计算建模和组织学/微观结构分析等多种方法。回顾了定量力学数据的显著发现。我们通过讨论一些未来研究感兴趣的未解决问题来结束本文。
