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2015 - 2050年撒哈拉以南非洲地区艾滋病防控的长期融资需求:一项建模研究

Long-term financing needs for HIV control in sub-Saharan Africa in 2015-2050: a modelling study.

作者信息

Atun Rifat, Chang Angela Y, Ogbuoji Osondu, Silva Sachin, Resch Stephen, Hontelez Jan, Bärnighausen Till

机构信息

Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.

出版信息

BMJ Open. 2016 Mar 6;6(3):e009656. doi: 10.1136/bmjopen-2015-009656.

Abstract

OBJECTIVES

To estimate the present value of current and future funding needed for HIV treatment and prevention in 9 sub-Saharan African (SSA) countries that account for 70% of HIV burden in Africa under different scenarios of intervention scale-up. To analyse the gaps between current expenditures and funding obligation, and discuss the policy implications of future financing needs.

DESIGN

We used the Goals module from Spectrum, and applied the most up-to-date cost and coverage data to provide a range of estimates for future financing obligations. The four different scale-up scenarios vary by treatment initiation threshold and service coverage level. We compared the model projections to current domestic and international financial sources available in selected SSA countries.

RESULTS

In the 9 SSA countries, the estimated resources required for HIV prevention and treatment in 2015-2050 range from US$98 billion to maintain current coverage levels for treatment and prevention with eligibility for treatment initiation at CD4 count of <500/mm(3) to US$261 billion if treatment were to be extended to all HIV-positive individuals and prevention scaled up. With the addition of new funding obligations for HIV--which arise implicitly through commitment to achieve higher than current treatment coverage levels--overall financial obligations (sum of debt levels and the present value of the stock of future HIV funding obligations) would rise substantially.

CONCLUSIONS

Investing upfront in scale-up of HIV services to achieve high coverage levels will reduce HIV incidence, prevention and future treatment expenditures by realising long-term preventive effects of ART to reduce HIV transmission. Future obligations are too substantial for most SSA countries to be met from domestic sources alone. New sources of funding, in addition to domestic sources, include innovative financing. Debt sustainability for sustained HIV response is an urgent imperative for affected countries and donors.

摘要

目标

评估撒哈拉以南非洲地区9个国家在不同干预扩大规模情景下,当前及未来用于艾滋病治疗和预防所需资金的现值。这9个国家的艾滋病负担占非洲的70%。分析当前支出与资金义务之间的差距,并探讨未来融资需求的政策含义。

设计

我们使用了Spectrum中的目标模块,并应用最新的成本和覆盖数据,对未来的融资义务提供一系列估计。四种不同的扩大规模情景因治疗启动阈值和服务覆盖水平而异。我们将模型预测与选定的撒哈拉以南非洲国家现有的国内和国际资金来源进行了比较。

结果

在这9个撒哈拉以南非洲国家,2015年至2050年期间,艾滋病预防和治疗所需的估计资源从980亿美元到2610亿美元不等。980亿美元是维持当前治疗和预防覆盖水平(治疗启动的CD4细胞计数阈值为<500/mm³)所需的资金,而如果将治疗扩展到所有艾滋病毒阳性个体并扩大预防规模,则需要2610亿美元。随着因承诺实现高于当前治疗覆盖水平而隐含产生的艾滋病新资金义务的增加,总体财务义务(债务水平与未来艾滋病资金义务存量的现值之和)将大幅上升。

结论

预先投资扩大艾滋病服务规模以实现高覆盖水平,将通过实现抗逆转录病毒治疗的长期预防效果以减少艾滋病毒传播,从而降低艾滋病毒发病率、预防成本和未来的治疗支出。对大多数撒哈拉以南非洲国家来说,仅靠国内来源无法满足未来如此巨大的义务。除国内来源外,新的资金来源包括创新融资。受影响国家和捐助方迫切需要实现可持续的债务水平,以持续应对艾滋病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0885/4785296/e6d3625775f8/bmjopen2015009656f01.jpg

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