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巨噬细胞与病毒传播的“超级高速公路”

Macrophages and the Viral Dissemination Super Highway.

作者信息

Klepper Arielle, Branch Andrea D

机构信息

Division of Liver Diseases, Department of Medicine, Mount Sinai Medical Center, USA.

出版信息

EC Microbiol. 2015;2(3):328-336.

Abstract

Monocytes and macrophages are key components of the innate immune system yet they are often the victims of attack by infectious agents. This review examines the significance of viral infection of macrophages. The central hypothesis is that macrophage tropism enhances viral dissemination and persistence, but these changes may come at the cost of reduced replication in cells other than macrophages.

摘要

单核细胞和巨噬细胞是固有免疫系统的关键组成部分,但它们常常成为感染因子攻击的对象。本综述探讨了巨噬细胞病毒感染的意义。核心假说是巨噬细胞嗜性增强了病毒的传播和持续性,但这些变化可能是以巨噬细胞以外的细胞中病毒复制减少为代价的。

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