Molecular Virology Section, Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Cell Mol Life Sci. 2010 Aug;67(16):2773-86. doi: 10.1007/s00018-010-0357-z. Epub 2010 Apr 6.
Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50-100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious life cycle of DENV and will discuss the viral and host factors that are important in controlling DENV infection.
登革病毒（DENV1-4）是一种主要的新发节肢动物传播病原体。所有四种 DENV 血清型在世界（亚热带）热带地区流行，每年感染 5000 万至 1 亿人。虽然大多数 DENV 感染无症状或导致自限性登革热，但越来越多的患者出现更严重的表现，如登革出血热和登革休克综合征。在这篇综述中，我们将概述 DENV 的感染生命周期，并讨论在控制 DENV 感染中重要的病毒和宿主因素。
