Richards K S, Morris D L, Taylor D H
Parasitology Research Laboratory, University of Keele, Staffordshire, U.K.
Ann Trop Med Parasitol. 1989 Oct;83(5):479-84. doi: 10.1080/00034983.1989.11812375.
Cotton rats with Echinococcus multilocularis infections of one month's standing were treated for six months with albendazole (50 mg kg-1 day-1), or praziquantel (500 mg kg-1 day-1), or both drugs simultaneously. The germinal layer of albendazole-treated cysts differed little from control tissue apart from marginal increase in cyton vesiculation and the presence of small lamellated residual bodies. Protoscolex tissue appeared unaffected. The germinal layer of praziquantel-treated cysts differed markedly from control tissue, with increased vesiculation and mitochondrial number in those with intact germinal layers, and disintegration and detachment of the layer in other cysts. Protoscoleces were necrotic. After combined therapy, the germinal layer was either intact but with increased vesiculation and residual bodies present, or was disintegrating and detaching from the laminated layer.
感染多房棘球绦虫达1个月的棉鼠，用阿苯达唑（50毫克/千克/天）、吡喹酮（500毫克/千克/天）治疗6个月，或同时使用这两种药物。接受阿苯达唑治疗的囊肿生发层与对照组织相比差异不大，只是细胞泡增多和出现小的层状残余体。原头节组织似乎未受影响。接受吡喹酮治疗的囊肿生发层与对照组织有明显差异，生发层完整的囊肿泡和线粒体数量增加，其他囊肿生发层则解体和脱离。原头节坏死。联合治疗后，生发层要么完整但泡和残余体增多，要么正在解体并与板层脱离。
