多房棘球绦虫：阿苯达唑和吡喹酮治疗的体内结果

Echinococcus multilocularis: in vivo results of therapy with albendazole and praziquantel.

作者信息

Taylor D H, Morris D L, Richards K S, Reffin D

机构信息

Department of Surgery, University Hospital, Nottingham, UK.

出版信息

Trans R Soc Trop Med Hyg. 1988;82(4):611-5. doi: 10.1016/0035-9203(88)90528-7.

DOI:10.1016/0035-9203(88)90528-7

PMID:3076717

Abstract

The effects of albendazole and praziquantel on the growth of Echinococcus multilocularis were studied in cotton rats. Albendazole (20 and 50 mg/kg) reduced parasite weight and increased the length of survival of infected animals but viable infection was present after treatment. In an in vitro system albendazole sulphoxide entered cysts of E. multilocularis passively. Praziquantel 100 mg/kg was ineffective but 500 mg/kg significantly inhibited growth. A combination of albendazole and praziquantel was no more effective than either agent alone.

摘要

在棉鼠中研究了阿苯达唑和吡喹酮对多房棘球绦虫生长的影响。阿苯达唑（20和50毫克/千克）可减轻寄生虫重量并延长感染动物的存活时间，但治疗后仍存在活感染。在体外系统中，阿苯达唑亚砜被动进入多房棘球绦虫的囊肿。100毫克/千克的吡喹酮无效，但500毫克/千克可显著抑制生长。阿苯达唑和吡喹酮联合使用并不比单独使用任何一种药物更有效。