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来自c-Ha-ras-I癌基因启动子区域的两种序列特异性结合蛋白。

Two sequence-specific binding proteins from the promoter region of the c-Ha-ras-I oncogene.

作者信息

Dimitrov T

机构信息

Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, Sofia.

出版信息

Biochem Genet. 1989 Aug;27(7-8):395-402. doi: 10.1007/BF02399668.

DOI:10.1007/BF02399668
PMID:2695058
Abstract

The role of sequence-specific binding proteins in transcriptional control in higher eukaryotes is unclear. We have investigated the control region of the c-Ha-ras-I protooncogene containing upstream sequences from the transcriptional initiation point. Two proteins, which bind these sequences, with molecular weights of 20 K and 43 K were found. The possible role in the process of transformation is discussed.

摘要

序列特异性结合蛋白在高等真核生物转录调控中的作用尚不清楚。我们研究了c-Ha-ras-I原癌基因的调控区域，该区域包含转录起始点上游的序列。发现了两种与这些序列结合的蛋白质，分子量分别为20K和43K。并讨论了其在转化过程中的可能作用。

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beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein.β-半乳糖苷酶嵌合体：乳糖阻遏蛋白-β-半乳糖苷酶蛋白的一级结构
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