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1
Inhibition of the formation of the complement membrane-attack complex by a monoclonal antibody to the complement component C8 alpha subunit.一种针对补体成分C8α亚基的单克隆抗体对补体膜攻击复合物形成的抑制作用。
Biochem J. 1989 Dec 15;264(3):933-6. doi: 10.1042/bj2640933.
2
Complement pores in erythrocyte membranes. Analysis of C8/C9 binding required for functional membrane damage.红细胞膜上的补体孔道。对功能性膜损伤所需的C8/C9结合的分析。
Biochim Biophys Acta. 1983 Aug 10;732(3):541-52. doi: 10.1016/0005-2736(83)90230-4.
3
Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly.补体膜攻击复合物中C9的分子组织。C5b-8组装诱导C9环状聚合。
J Exp Med. 1982 Jul 1;156(1):268-82. doi: 10.1084/jem.156.1.268.
4
Antigenic crossreactivity of the alpha subunit of complement component C8 with the cysteine-rich domain shared by complement component C9 and low density lipoprotein receptor.补体成分C8的α亚基与补体成分C9和低密度脂蛋白受体共有的富含半胱氨酸结构域之间的抗原交叉反应性。
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4223-7. doi: 10.1073/pnas.83.12.4223.
5
Measurement of the ratio of the eighth and ninth components of human complement on complement-lysed membranes.补体溶解膜上人类补体第八和第九成分比例的测定。
Biochemistry. 1984 Aug 28;23(18):4016-22. doi: 10.1021/bi00313a002.
6
Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9.III型阵发性夜间血红蛋白尿。缺乏限制C5b-9介导红细胞溶解的红细胞膜蛋白。
J Clin Invest. 1987 Jul;80(1):7-12. doi: 10.1172/JCI113065.
7
Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels.一种能够抑制同源补体跨膜通道表达的人红细胞膜蛋白的分离。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6975-9. doi: 10.1073/pnas.83.18.6975.
8
Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement.旋毛虫肌球蛋白结合 C8 和 C9 并保护组织内寄生线虫免受宿主补体的攻击。
PLoS Negl Trop Dis. 2011 Jul;5(7):e1225. doi: 10.1371/journal.pntd.0001225. Epub 2011 Jul 5.
9
Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.靶标缺失补体成分 9 可减轻小鼠抗体介导的溶血和脂多糖（LPS）诱导的急性休克。
Sci Rep. 2016 Jul 22;6:30239. doi: 10.1038/srep30239.
10
Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9.CD59对同源补体的抑制作用是通过与C5b-8中的C8或C5b-9中的C9结合所赋予的物种选择性识别来介导的。
J Immunol. 1991 Apr 1;146(7):2345-51.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Role of the beta subunit in interaction of the eighth component of human complement with the membrane-bound cytolytic complex.β亚基在人补体第八成分与膜结合溶细胞复合物相互作用中的作用。
J Biol Chem. 1981 Apr 10;256(7):3258-62.
3
Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9.亲水性补体蛋白C9通过自发聚合形成跨膜小管。
Nature. 1982 Aug 5;298(5874):534-8. doi: 10.1038/298534a0.
4
Ultrastructure of the membrane attack complex of complement: detection of the tetramolecular C9-polymerizing complex C5b-8.补体膜攻击复合物的超微结构：四聚体C9聚合复合物C5b-8的检测
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7474-8. doi: 10.1073/pnas.79.23.7474.
5
Studies of the association of the eighth and ninth components of human complement within the membrane-bound cytolytic complex.关于人类补体第八和第九成分在膜结合溶细胞复合物中的关联研究。
J Biol Chem. 1983 Apr 25;258(8):5056-62.
6
Inhibition of complement-induced [14C]sucrose release by intracellular and extracellular monoclonal antibodies to C9: evidence that C9 is a transmembrane protein.细胞内和细胞外针对C9的单克隆抗体对补体诱导的[14C]蔗糖释放的抑制作用：证明C9是一种跨膜蛋白。
Biochem Biophys Res Commun. 1984 Jan 30;118(2):616-22. doi: 10.1016/0006-291x(84)91347-0.
7
Immunoaffinity purification of human complement component C9 using monoclonal antibodies.使用单克隆抗体对人补体成分C9进行免疫亲和纯化。
J Immunol Methods. 1983 Nov 25;64(3):269-81. doi: 10.1016/0022-1759(83)90434-9.
8
Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly.补体膜攻击复合物中C9的分子组织。C5b-8组装诱导C9环状聚合。
J Exp Med. 1982 Jul 1;156(1):268-82. doi: 10.1084/jem.156.1.268.
9
Analysis of the specific association of the eighth and ninth components of human complement: identification of a direct role for the alpha subunit of C8.人类补体第八和第九成分的特异性关联分析：C8α亚基直接作用的鉴定
Biochemistry. 1985 Aug 13;24(17):4598-602. doi: 10.1021/bi00338a018.
10
Immunocytochemical localisation of complement components C8 and C9 in human diseased muscle. The role of complement in muscle fibre damage.补体成分C8和C9在人类病变肌肉中的免疫细胞化学定位。补体在肌纤维损伤中的作用。
J Neurol Sci. 1987 Nov;81(2-3):141-53. doi: 10.1016/0022-510x(87)90091-8.

一种针对补体成分C8α亚基的单克隆抗体对补体膜攻击复合物形成的抑制作用。

Inhibition of the formation of the complement membrane-attack complex by a monoclonal antibody to the complement component C8 alpha subunit.

作者信息

Abraha A, Luzio J P

机构信息

Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, U.K.

出版信息

Biochem J. 1989 Dec 15;264(3):933-6. doi: 10.1042/bj2640933.

DOI:10.1042/bj2640933
PMID:2695070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1133676/
Abstract

The effect of nine monoclonal antibodies to complement component C8 on the interaction of C9 with preformed cell-surface C5b-8 complexes and on the functional insertion of C8 into the membrane-attack complex (MAC) was investigated. None of the antibodies prevented C9 insertion into a preformed C5b-8 complex. One antibody (F1) directed to the C8 alpha subunit clearly inhibited formation of a functional MAC. It is proposed that this antibody prevents the C8 alpha subunit unfolding and distorting the bilayer to allow C9 insertion.

摘要

研究了九种针对补体成分C8的单克隆抗体对C9与预先形成的细胞表面C5b-8复合物相互作用以及C8功能性插入膜攻击复合物（MAC）的影响。没有一种抗体能阻止C9插入预先形成的C5b-8复合物。一种针对C8α亚基的抗体（F1）明显抑制功能性MAC的形成。据推测，该抗体可阻止C8α亚基展开并扭曲双层膜以允许C9插入。