一种针对补体成分C8α亚基的单克隆抗体对补体膜攻击复合物形成的抑制作用。
Inhibition of the formation of the complement membrane-attack complex by a monoclonal antibody to the complement component C8 alpha subunit.
作者信息
Abraha A, Luzio J P
机构信息
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, U.K.
出版信息
Biochem J. 1989 Dec 15;264(3):933-6. doi: 10.1042/bj2640933.
Abstract
The effect of nine monoclonal antibodies to complement component C8 on the interaction of C9 with preformed cell-surface C5b-8 complexes and on the functional insertion of C8 into the membrane-attack complex (MAC) was investigated. None of the antibodies prevented C9 insertion into a preformed C5b-8 complex. One antibody (F1) directed to the C8 alpha subunit clearly inhibited formation of a functional MAC. It is proposed that this antibody prevents the C8 alpha subunit unfolding and distorting the bilayer to allow C9 insertion.
摘要
研究了九种针对补体成分C8的单克隆抗体对C9与预先形成的细胞表面C5b-8复合物相互作用以及C8功能性插入膜攻击复合物（MAC）的影响。没有一种抗体能阻止C9插入预先形成的C5b-8复合物。一种针对C8α亚基的抗体（F1）明显抑制功能性MAC的形成。据推测，该抗体可阻止C8α亚基展开并扭曲双层膜以允许C9插入。
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