Burgess A W, Cebon J, Smith S
Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.
Biochem Soc Symp. 1989;55:57-68.
Endotoxin induces the appearance of granulocyte colony stimulating factor (G-CSF) and macrophage (M)-CSF in the serum of mice. No GM-CSF was detectable in endotoxin serum. Phytohaemagglutinin stimulated human T-lymphocytes to secrete three major forms of GM-CSF. All of the haemopoietic growth factors (HGFs) are active in vivo, but the cellular responses are different for each HGF. Prolonged administration of G-CSF increases the number of circulating neutrophils and does not lead to adverse side-effects. Chronic exposure to GM-CSF induces an accumulation of activated macrophages which can cause considerable tissue destruction. Although the 'src-like' oncogenes induce HGF production by chicken myeloblasts, factor-dependent murine cells can be converted to a tumorigenic phenotype without autocrine growth factor production.
内毒素可诱导小鼠血清中出现粒细胞集落刺激因子（G-CSF）和巨噬细胞（M）-CSF。在内毒素血清中未检测到GM-CSF。植物血凝素刺激人T淋巴细胞分泌三种主要形式的GM-CSF。所有造血生长因子（HGFs）在体内均有活性，但每种HGF的细胞反应不同。长期给予G-CSF可增加循环中性粒细胞的数量，且不会导致不良副作用。长期暴露于GM-CSF会诱导活化巨噬细胞的积累，这可能会导致相当程度的组织破坏。尽管“src样”癌基因可诱导鸡成髓细胞产生HGF，但因子依赖性小鼠细胞可在不产生自分泌生长因子的情况下转化为致瘤表型。
