Trzesniak Clarissa, Araújo David, Crippa José Alexandre S
1Department of Neuropsychiatry and Medical Psychology, Ribeirão Preto Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Acta Neuropsychiatr. 2008 Apr;20(2):56-71. doi: 10.1111/j.1601-5215.2008.00270.x.
Magnetic resonance spectroscopy (MRS) is a non-invasive in vivo method used to quantify metabolites that are relevant to a wide range of brain processes. This paper briefly describes neuroimaging using MRS and provides a systematic review of its application to anxiety disorders.
A literature review was performed in the PubMed, Lilacs and Scielo databases using the keywords spectroscopy and anxiety disorder. References of selected articles were also hand-searched for additional citations.
Recent studies have shown that there are significant metabolic differences between patients with anxiety disorders and healthy controls in various regions of the brain. Changes were mainly found in N-acetylaspartate, which is associated with neuronal viability, but some of them were also seen in creatine, a substance that is thought to be relatively constant among individuals with different pathological conditions.
MRS is a sophisticated neuroimaging technique that has provided useful insights into the biochemical and neurobiological basis of many anxiety disorders. Nevertheless, its utilization in some anxiety disorders is still modest, particularly social phobia and generalised anxiety. Although it is an extremely useful advance in neuroimaging, further research in other brain areas and patient populations is highly advisable.
磁共振波谱（MRS）是一种非侵入性的体内方法，用于量化与多种脑过程相关的代谢物。本文简要描述了使用MRS的神经影像学，并对其在焦虑症中的应用进行了系统综述。
在PubMed、Lilacs和Scielo数据库中使用关键词“波谱学”和“焦虑症”进行文献综述。还对所选文章的参考文献进行了手工检索以获取更多引用。
最近的研究表明，焦虑症患者与健康对照者在大脑的各个区域存在显著的代谢差异。变化主要见于与神经元活力相关的N-乙酰天门冬氨酸，但在肌酸中也有一些变化，肌酸被认为在不同病理状况的个体中相对稳定。
MRS是一种先进的神经影像学技术，为许多焦虑症的生化和神经生物学基础提供了有用的见解。然而，它在某些焦虑症中的应用仍然有限，尤其是社交恐惧症和广泛性焦虑症。尽管它是神经影像学方面极其有用的进展，但非常有必要在其他脑区和患者群体中进行进一步研究。
