Malhi Gin S, Valenzuela Michael, Wen Wei, Sachdev Perminder
Mood Disorders Unit, The Villa, Prince of Wales Hospital, Randwick NSW 2031, Sydney, Australia.
Aust N Z J Psychiatry. 2002 Feb;36(1):31-43. doi: 10.1046/j.1440-1614.2002.00992.x.
This paper briefly describes neuroimaging using magnetic resonance spectroscopy (MRS) and provides a systematic review of its application to psychiatric disorders.
A literature review (Index Medicus/Medline) was carried out, as well as a review of other relevant papers and data known to the authors.
Magnetic resonance spectroscopy is a complex and sophisticated neuroimaging technique that allows reliable and reproducible quantification of brain neurochemistry provided its limitations are respected. In some branches of medicine it is already used clinically, for instance, to diagnose tumours and in psychiatry its applications are gradually extending beyond research. Neurochemical changes have been found in a variety of brain regions in dementia, schizophrenia and affective disorders and promising discoveries have also been made in anxiety disorders.
Magnetic resonance spectroscopy is a non-invasive investigative technique that has provided useful insights into the biochemical basis of many neuropsychiatric disorders. It allows direct measurement, in vivo, of medication levels within the brain and has made it possible to track the neurochemical changes that occur as a consequence of disease and ageing or in response to treatment. It is an extremely useful advance in neuroimaging technology and one that will undoubtedly have many clinical uses in the near future.
本文简要介绍了利用磁共振波谱（MRS）进行的神经影像学检查，并对其在精神疾病中的应用进行了系统综述。
进行了文献综述（医学索引/医学期刊数据库），并对作者所知的其他相关论文和数据进行了回顾。
磁共振波谱是一种复杂而精密的神经影像学技术，只要尊重其局限性，就能对脑内神经化学物质进行可靠且可重复的定量分析。在医学的某些领域，它已用于临床诊断，例如肿瘤诊断，在精神病学领域，其应用正逐渐从研究扩展到临床。在痴呆症、精神分裂症和情感障碍的多种脑区中均发现了神经化学变化，在焦虑症方面也有了一些有前景的发现。
磁共振波谱是一种非侵入性的检查技术，为许多神经精神疾病的生化基础提供了有用的见解。它能够在体内直接测量脑内的药物水平，并追踪因疾病、衰老或治疗引起的神经化学变化。这是神经影像学技术的一项极其有用的进展，无疑在不久的将来会有许多临床应用。
