Katoch Saloni, Kallappa Ravindra, Shamanur Murugesh B, Gandhi Sneha
Department of Dermatology, Venereology and Leprology, Jagadguru Jayadeva Murugarajendra Medical College, Davangere, Karnataka, India.
Indian Dermatol Online J. 2016 Jan-Feb;7(1):24-8. doi: 10.4103/2229-5178.174324.
Purpura fulminans (PF) is a descriptive term used to describe a heterogeneous group of disorders characterized by rapidly progressive purpuric lesions that may develop into extensive areas of skin necrosis, and peripheral gangrene. This rare disorder is associated with laboratory evidence of consumptive coagulopathy and is often fatal. PF is usually associated with many infections, most notably with meningococcal, staphylococcal, and streptococcal infections. However, there are very few reports of this entity with spotted fever and scrub typhus from India. Rickettsial infections are an underdiagnosed group of diseases presenting as acute febrile illness, with high mortality in untreated cases. Of the available tests, Weil-Felix is a handy and economical tool for early diagnosis of this fatal disease especially in resource poor settings. We present four infants with PF secondary to rickettsial fever diagnosed by the Weil-Felix test.
暴发性紫癜（PF）是一个描述性术语，用于描述一组异质性疾病，其特征为迅速进展的紫癜性病变，可发展为广泛的皮肤坏死区域及外周坏疽。这种罕见疾病与消耗性凝血病的实验室证据相关，且往往致命。PF通常与多种感染有关，最显著的是脑膜炎球菌、葡萄球菌和链球菌感染。然而，来自印度的关于斑疹热和恙虫病并发该疾病实体的报道极少。立克次体感染是一组诊断不足的疾病，表现为急性发热性疾病，未经治疗的病例死亡率很高。在现有的检测方法中，外斐反应是早期诊断这种致命疾病的便捷且经济的工具，尤其是在资源匮乏的环境中。我们报告了4例通过外斐反应试验诊断为立克次体热继发暴发性紫癜的婴儿。
