Huang Chih-Cheng, Lee Jong-Jer, Lin Tsu-Kung, Tsai Nai-Wen, Huang Chi-Ren, Chen Shu-Fang, Lu Cheng-Hsien, Liu Rue-Tsuan
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
J Diabetes Res. 2016;2016:6090749. doi: 10.1155/2016/6090749. Epub 2016 Feb 3.
A well-established, comprehensive, and simple test battery was used here to re-evaluate risk factors for cardiovascular autonomic neuropathy (CAN) in type 2 diabetes. One hundred and seventy-four patients with type 2 diabetes were evaluated through the methods of deep breathing and Valsalva maneuver for correlation with factors that might influence the presence and severity of CAN. The Composite Autonomic Scoring Scale (CASS) was used to grade the severity of autonomic impairment, and CAN was defined as a CASS score ≥2. Results showed that nephropathy, duration of diabetes, blood pressure, uric acid, and the presence of retinopathy and metabolic syndrome significantly correlated with the CASS score. Age may not be a risk factor for diabetic CAN. However, the effects of diabetes on CAN are more prominent in younger patients than in older ones. Diabetic retinopathy is the most significant risk factor predictive of the presence of CAN in patients with type 2 diabetes.
在此，我们使用了一套成熟、全面且简单的测试组合来重新评估2型糖尿病患者心血管自主神经病变（CAN）的危险因素。通过深呼吸和瓦尔萨尔瓦动作的方法对174例2型糖尿病患者进行评估，以确定其与可能影响CAN存在及严重程度的因素之间的相关性。使用综合自主神经评分量表（CASS）对自主神经损伤的严重程度进行分级，CAN定义为CASS评分≥2。结果显示，肾病、糖尿病病程、血压、尿酸、视网膜病变的存在以及代谢综合征与CASS评分显著相关。年龄可能不是糖尿病性CAN的危险因素。然而，糖尿病对CAN的影响在年轻患者中比在老年患者中更为显著。糖尿病视网膜病变是预测2型糖尿病患者存在CAN的最显著危险因素。
