Samaranayake L P, Holmstrup P
Department of Oral Medicine and Pathology, Glasgow Dental Hospital and School, Scotland.
J Oral Pathol Med. 1989 Dec;18(10):554-64. doi: 10.1111/j.1600-0714.1989.tb01552.x.
The association of oral candidiasis with the human immunodeficiency virus (HIV) infection has been known since the advent of the acquired immunodeficiency syndrome (AIDS) pandemic. Oral candidiasis is one of the earliest premonitory signs of HIV infection and its diagnosis may have grave prognostic implications for the eventual development of full blown AIDS. There is now an expanding body of data on novel clinical variants of this 'old' disease, its epidemiology in HIV seropositive individuals and, advances in its management, particularly with respect to the recently introduced bis-triazole antifungals. Current concepts pertaining to the epidemiology, clinical features, pathogenesis, laboratory diagnosis and management of oral candidiasis in HIV infection are reviewed.
自获得性免疫缺陷综合征（艾滋病）大流行出现以来，口腔念珠菌病与人类免疫缺陷病毒（HIV）感染之间的关联就已为人所知。口腔念珠菌病是HIV感染最早的先兆症状之一，其诊断可能对全面发展成艾滋病的最终预后产生严重影响。目前，关于这种“老”疾病的新型临床变体、其在HIV血清阳性个体中的流行病学以及治疗进展，特别是关于最近引入的双三唑类抗真菌药物的相关数据正在不断增加。本文综述了当前有关HIV感染中口腔念珠菌病的流行病学、临床特征、发病机制、实验室诊断及治疗的相关概念。
