Nicolatou O, Theodoridou M, Mostrou G, Velegraki A, Legakis N J
Department of Oral Pathology and Surgery, School of Dentistry, University of Athens, Greece.
J Oral Pathol Med. 1999 Feb;28(2):49-53. doi: 10.1111/j.1600-0714.1999.tb01995.x.
Fifteen vertically HIV-infected children aged between 2 and 12 years were followed up for 1 year, weekly to monthly, to study the incidence of oral lesions. At the time of first examination, oral candidiasis (OC) was observed in nine children. Seven children presented with the erythematous type only and two with pseudomembranous oral candidiasis. Four cases of cheilitis were seen in association with the erythematous forms of oral candidiasis. One erythematous candidiasis progressed to pseudomembranous form. A second case of erythematous OC, after multiple recurrences in the form of erythematous OC, recurred as pseudomembranous OC. Another case of erythematous OC and one of pseudomembranous OC presented after multiple recurrences as a persistent, adherent pseudomembranous OC. An orofacial herpes-zoster infection, a hairy leukoplakia and a necrotic lingual ulcer were observed as second lesions and in association with oral candidiasis in three children. Erythematous oral candidiasis was the most frequent oral HIV-related lesion, was observed in different stages of HIV-infection, and in some cases progressed to pseudomembranous candidiasis. A different, selectively resistant, Candida clone was isolated in three cases of recurrent candidiasis.
对15名年龄在2至12岁之间的垂直感染艾滋病毒的儿童进行了为期1年的随访，随访频率为每周至每月一次，以研究口腔病变的发生率。在首次检查时，9名儿童观察到口腔念珠菌病（OC）。7名儿童仅表现为红斑型，2名儿童表现为假膜性口腔念珠菌病。4例唇炎与红斑型口腔念珠菌病相关。1例红斑型念珠菌病进展为假膜型。1例红斑型OC在多次以红斑型OC复发后，复发为假膜型OC。另1例红斑型OC和1例假膜型OC在多次复发后表现为持续性、附着性假膜型OC。3名儿童观察到口面部带状疱疹感染、毛状白斑和坏死性舌溃疡作为继发病变并与口腔念珠菌病相关。红斑型口腔念珠菌病是最常见的与艾滋病毒相关的口腔病变，在艾滋病毒感染的不同阶段均有观察到，在某些情况下进展为假膜性念珠菌病。在3例复发性念珠菌病中分离出不同的、具有选择性耐药性的念珠菌克隆。
