Cancer Discov. 2016 Apr;6(4):OF1. doi: 10.1158/2159-8290.CD-NB2016-026. Epub 2016 Mar 8.
Although dendritic cells are abundant in ovarian tumors, scientists have been puzzled that these cells aren't immunostimulatory. New research reveals a role for the protein SATB1, which is transiently required during ovarian-associated dendritic cell maturation-its unremitting expression in these cells drives them to acquire an inflammatory, immunosuppressive phenotype.
尽管树突状细胞在卵巢肿瘤中很丰富，但科学家们一直感到困惑的是，这些细胞没有免疫刺激性。新的研究揭示了 SATB1 蛋白的作用，该蛋白在卵巢相关树突状细胞成熟过程中是暂时需要的——它在这些细胞中的持续表达驱使它们获得炎症性、免疫抑制表型。
