Cai Dong Li, Jin Li-Ping
Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China.
J Cancer. 2017 Aug 25;8(15):2915-2923. doi: 10.7150/jca.20314. eCollection 2017.
Ovarian cancer, the third most common with highest mortality rates gynecological malignancy among women in China, is characterized by a unique tumor immune microenvironment. Immune-cell population infiltrated into the tumor tissue among patients with ovarian cancer are associated positively or negatively with antitumor activity. The imbalance between immune activation and immune suppression can result in oncogenesis and cancer progression. Therefore, intense investigation of the immunologic mechanism of ovarian cancer is urgently needed, and a comprehensive understanding of the network in which immune cells interact with the microenvironment, tumor cells and each other will greatly promote the development of more effective immunotherapies for ovarian cancer. In this review, we will focus on the main immune-cell population in ovarian tumor microenvironment, discuss their role in tumor progression and try to give the readers a new perspective in finding more promising therapeutic targets for cancers.
卵巢癌是中国女性中第三常见且死亡率最高的妇科恶性肿瘤，其特征在于独特的肿瘤免疫微环境。浸润到卵巢癌患者肿瘤组织中的免疫细胞群体与抗肿瘤活性呈正相关或负相关。免疫激活与免疫抑制之间的失衡可导致肿瘤发生和癌症进展。因此，迫切需要深入研究卵巢癌的免疫机制，全面了解免疫细胞与微环境、肿瘤细胞以及彼此之间相互作用的网络，这将极大地促进针对卵巢癌更有效免疫疗法的发展。在本综述中，我们将聚焦于卵巢肿瘤微环境中的主要免疫细胞群体，讨论它们在肿瘤进展中的作用，并试图为读者提供一个新的视角，以寻找更有前景的癌症治疗靶点。
