Asadi-Pooya Ali A
Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA.
Neurosciences Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Neurol Sci. 2016 Jul;37(7):1033-8. doi: 10.1007/s10072-016-2540-y. Epub 2016 Mar 8.
Psychogenic nonepileptic seizures (PNES) are relatively common occurrences in epilepsy centers, but their pathophysiology is still poorly understood. Research that elucidates the pathophysiology of PNES, including their neurobiological basis and biomarkers, may have important clinical implications. The literature provides some evidence that genetic factors, intrinsic factors, and environmental factors probably play a significant role as the biological underpinnings of PNES. Researchers may be able to learn more about the pathophysiology of PNES by investigating the effects of each of these factors on functional and structural brain connectivity.
心理性非癫痫性发作（PNES）在癫痫中心较为常见，但其病理生理学仍未得到充分理解。阐明PNES病理生理学的研究，包括其神经生物学基础和生物标志物，可能具有重要的临床意义。文献提供了一些证据，表明遗传因素、内在因素和环境因素可能作为PNES的生物学基础发挥重要作用。研究人员或许能够通过研究这些因素中的每一个对大脑功能和结构连接性的影响，更多地了解PNES的病理生理学。
