在未经治疗的帕金森病患者中过早下结论。
Jumping to conclusions in untreated patients with Parkinson's disease.
作者信息
de Rezende Costa Flavio Henrique, Averbeck Bruno, O'Sullivan Sean S, Vincent Maurice Borges, Rosso Ana Lucia, Lees Andrew J, Djamshidian Atbin
机构信息
Neurology Department/Movement Disorders Sector, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-4415, United States.
出版信息
Neuropsychologia. 2016 May;85:19-23. doi: 10.1016/j.neuropsychologia.2016.03.002. Epub 2016 Mar 5.
BACKGROUND
Jumping to conclusions due to impulsivity has been shown to be a sensitive marker for dopamine dysregulation and addictive behaviour patterns in treated patients with Parkinson's disease (PD). It is unknown whether drug naïve PD patients, who have never received dopaminergic therapy also have deficits in information sampling.
METHODS
Twenty five de novo PD patients and twenty matched healthy controls were recruited and tested on the beads task, which is a validated information sampling task to assess reflection impulsivity and a temporal discounting questionnaire.
RESULTS
Patients gathered significantly less information and made more irrational choices than matched controls. There was, however, no group difference on the temporal discounting questionnaire.
CONCLUSIONS
Poor information sampling and irrational decision making may be an inherent component of the neuropsychological deficit in Parkinson's disease. These findings suggest that underlying impulsivity detected by a metric task is common in de novo PD.
背景
在接受治疗的帕金森病（PD）患者中，因冲动而草率下结论已被证明是多巴胺调节异常和成瘾行为模式的一个敏感指标。从未接受过多巴胺能治疗的初发PD患者在信息采样方面是否也存在缺陷尚不清楚。
方法
招募了25名初发PD患者和20名匹配的健康对照者，并对他们进行了珠子任务测试，这是一项经过验证的用于评估反射冲动性的信息采样任务，同时还进行了时间折扣问卷测试。
结果
与匹配的对照组相比，患者收集的信息明显更少，做出的非理性选择更多。然而，在时间折扣问卷上两组没有差异。
结论
信息采样不佳和决策非理性可能是帕金森病神经心理缺陷的一个固有组成部分。这些发现表明，通过一项度量任务检测到的潜在冲动性在初发PD中很常见。
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