1st Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, 72-74, Vassilissis Sofias Av., 11528, Athens, Greece.
1st Department of Psychiatry, Aeginition Hospital, National and Kapodistrian University of Athens, 72-74 Vas. Sofias Av., Athens, Greece.
J Neurol. 2023 Dec;270(12):5773-5783. doi: 10.1007/s00415-023-11904-x. Epub 2023 Aug 9.
The aim was to explore the correlations between Jumping to Conclusions (JtC) tendency and neuropsychiatric features in patients with early Parkinson's disease (PD).
According to few reports, PD patients with impulsive-compulsive behaviors (ICBs) are prone to working memory difficulties including JtC bias. The correlation of psychotic features and JtC tendency remains still unclear.
Healthy controls and patients within 3 years of PD onset were recruited. Participants were examined for psychotic symptoms using a 10 question PD-specific psychosis severity scale. JtC was measured by a probalistic reasoning scenario (beads task). In PD group, medication use, motor and non-motor symptoms were documented. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in PD (QUIP).
The prevalence of JtC bias was 9% (6/70) in healthy individuals, compared to 32% (22/68) of PD group [p = 0.001]. No association was detected between the presence of JtC tendency and PD-associated psychosis (p = 0.216). Patients with JtC had shorter duration of PD, more tremor-dominant PD subtype and higher QUIP scores, regardless of the dopaminergic therapy (p = 0.043, p = 0.015, p = 0.007, respectively). A trend towards attention and inhibition control deficit was noticed in JtC patients.
We found a high prevalence of JtC bias in early, cognitively intact PD population and a potential link between subthreshold ICBs and poor performance on beads task. Additional studies are needed to confirm our results and elaborate on the mechanisms that correlate impulsivity with JtC tendency, which are likely to be different from those mediating psychotic features in early PD.
本研究旨在探讨早期帕金森病（PD）患者跳跃式思维（JtC）倾向与神经精神特征之间的相关性。
根据少数报道，伴有冲动-强迫行为（ICBs）的 PD 患者易出现工作记忆困难，包括 JtC 偏差。精神特征与 JtC 倾向之间的相关性仍不清楚。
招募了健康对照组和 PD 发病后 3 年内的患者。使用专门针对 PD 的精神病严重程度的 10 个问题问卷评估参与者的精神病症状。通过概率推理情景（珠子任务）测量 JtC。在 PD 组中，记录药物使用、运动和非运动症状。使用 PD 冲动-强迫障碍问卷（QUIP）评估冲动性。
健康个体中 JtC 偏差的患病率为 9%（6/70），而 PD 组为 32%（22/68）[p=0.001]。未发现 JtC 倾向与 PD 相关精神病之间存在关联（p=0.216）。无论是否接受多巴胺能治疗，存在 JtC 倾向的患者 PD 持续时间更短、震颤为主型 PD 亚型更多、QUIP 评分更高（p=0.043、p=0.015、p=0.007）。在 JtC 患者中，注意和抑制控制缺陷的趋势更为明显。
我们发现，在认知正常的早期 PD 人群中，JtC 偏差的患病率较高，并且亚临床 ICB 与珠子任务表现不佳之间存在潜在联系。需要进一步的研究来证实我们的结果，并详细阐述与冲动性相关的 JtC 倾向的机制，这些机制可能与早期 PD 中精神特征的机制不同。
